A high-throughput response to the SARS-CoV-2 pandemic

被引：3

作者：

Rasmussen, Lynn ^{[1
]}

Sanders, Shalisa ^{[1
]}

Sosa, Melinda ^{[1
]}

Mckellip, Sara ^{[1
]}

Nebane, N. Miranda ^{[1
]}

Martinez-Gzegozewska, Yohanka ^{[1
]}

Reece, Andrew ^{[1
]}

Ruiz, Pedro ^{[1
]}

Manuvakhova, Anna ^{[1
]}

Zhai, Ling ^{[1
]}

Warren, Brooke ^{[1
]}

Curry, Aliyah ^{[1
]}

Zeng, Qinghua ^{[1
]}

Bostwick, J. Robert ^{[1
]}

Vinson, Paige N. ^{[1
]}

机构：

[1] Southern Res, Birmingham, AL 35294 USA

来源：

SLAS DISCOVERY | 2024年 / 29卷 / 05期

关键词：

SARS-CoV-2; SARS; SARS2; SARS-CoV; MERS; COVID; COVID-19; Pandemic; Antiviral; High-throughput; HTS; BSL-3; Coronavirus; Drug discovery; RESPIRATORY SYNCYTIAL VIRUS; INHIBITORS; IDENTIFICATION; REPLICATION; DISCOVERY; LIBRARY; SCREEN; ASSAYS; SARS;

D O I：

10.1016/j.slasd.2024.100160

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Four years after the beginning of the COVID-19 pandemic, it is important to reflect on the events that have occurred during that time and the knowledge that has been gained. The response to the pandemic was rapid and highly resourced; it was also built upon a foundation of decades of federally funded basic and applied research. Laboratories in government, pharmaceutical, academic, and non-profit institutions all played roles in advancing pre-2020 discoveries to produce clinical treatments. This perspective provides a summary of how the development of high-throughput screening methods in a biosafety level 3 (BSL-3) environment at Southern Research Institute (SR) contributed to pandemic response efforts. The challenges encountered are described, including those of a technical nature as well as those of working under the pressures of an unpredictable virus and pandemic.

引用

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