Family History in Parkinson's Disease: A National Cross-Sectional Study

被引：2

作者：

Arienti, Federica ^{[1
,2
]}

Casazza, Giovanni ^{[3
,4
]}

Franco, Giulia ^{[1
,2
]}

Lazzeri, Giulia ^{[2
,5
]}

Monfrini, Edoardo ^{[1
,2
]}

Di Maio, Alessandro ^{[1
,2
]}

Erro, Roberto ^{[6
]}

Barone, Paolo ^{[6
]}

Tamma, Filippo ^{[7
]}

Caputo, Elena ^{[7
]}

Volonte, Maria Antonietta ^{[8
]}

Cacciaguerra, Laura ^{[8
]}

Pilotto, Andrea ^{[9
,10
,11
,12
]}

Padovani, Alessandro ^{[9
,10
,11
,12
]}

Comi, Cristoforo ^{[13
]}

Magistrelli, Luca ^{[5
]}

Valzania, Franco ^{[14
]}

Cavallieri, Francesco ^{[14
]}

Avanzino, Laura ^{[15
,16
]}

Marchese, Roberta ^{[16
]}

Sensi, Mariachiara ^{[17
]}

Carroli, Giorgia ^{[17
]}

Eleopra, Roberto ^{[18
]}

Cilia, Roberto ^{[18
]}

Spagnolo, Francesca ^{[19
]}

Tessitore, Alessandro ^{[20
]}

De Micco, Rosa ^{[20
]}

Ceravolo, Roberto ^{[21
]}

Palermo, Giovanni ^{[21
]}

Malaguti, Maria Chiara ^{[22
]}

Lopiano, Leonardo ^{[23
,24
]}

Tocco, Pierluigi ^{[25
]}

Sorbera, Chiara ^{[26
]}

Tinazzi, Michele ^{[27
]}

Ciammola, Andrea ^{[28
]}

Ottaviani, Donatella ^{[29
]}

Valente, Enza Maria ^{[30
,31
]}

Albanese, Alberto ^{[32
]}

Blandini, Fabio ^{[4
]}

Canesi, Margherita ^{[33
]}

Antonini, Angelo ^{[34
]}

Carecchio, Miryam ^{[34
]}

Fetoni, Vincenza ^{[35
]}

Colosimo, Carlo ^{[36
]}

Volpe, Daniele ^{[37
]}

Tambasco, Nicola ^{[38
]}

Cossu, Giovanni ^{[39
]}

Zappia, Mario ^{[40
]}

Di Fonzo, Alessio ^{[1
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy

[2] Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Neurosci Sect, Milan, Italy

[3] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[5] Parkinson Inst, Gaetano Pini CTO, Milan, Italy

[6] Univ Salerno, Scuola Med Salernitana, Dept Med Surg & Dent, Neurosci Sect, Baronissi, SA, Italy

[7] F Miulli Gen Hosp, Dept Nephrol, I-70021 Acquaviva Delle Fonti, Italy

[8] IRCCS San Raffaele Sci Inst, Dept Neurol, Milan, Italy

[9] Univ Brescia, Neurol Unit, Brescia, Italy

[10] Univ Brescia, Neurobiorepository, Brescia, Italy

[11] Univ Brescia, Dept Clin & Expt Sci, Lab Adv Biol Markers, Brescia, Italy

[12] ASST Spedali Civili Brescia Hosp, Dept Continu Care & Frailty, Brescia, Italy

[13] Univ Piemonte Orientale, Dept Translat Med, Sect Neurol, Novara, Italy

[14] Azienda USL IRCCS Reggio Emilia, Neuromotor & Rehabil Dept, Neurol Unit, Reggio Emilia, Italy

[15] Univ Genoa, Dept Expt Med, Sect Human Physiol, Genoa, Italy

[16] IRCCS Osped Policlin San Martino, UOC Genet Med, Genoa, Italy

[17] Azienda Osped Univ S Anna, Dept Neurosci & Rehabil, Ferrara, Italy

[18] Fdn IRCCS Ist Neurol Carlo Besta, Dept Clin Neurosci, Movement Disorders Unit, Milan, Italy

[19] A Perrinos Hosp, Neurol Dept, Brindisi, Italy

[20] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Caserta, Italy

[21] Univ Pisa, Ctr Neurodegenerat Dis Parkinsons Dis & Movement D, Dept Clin & Expt Med, Unit Neurol, Pisa, Italy

[22] Azienda Prov & Serv Sanitaria APSS Trento, Trento Hosp, Neurol Unit, Trento, Italy

[23] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy

[24] AOU Citta Salute & Sci Torino, Neurol Unit 2, Turin, Italy

[25] Osped Pescara, Neurol & Stroke Unit, Pescara, Italy

[26] Neurorehabil Unit IRCCS Ctr Neurolesi Bonino Pulej, Messina, Messina, Italy

[27] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[28] Ist Auxol Italiano IRCCS, Dept Neurol & Lab Neurosci, Milan, Italy

[29] Azienda Prov & Serv Sanitari APSS Trento, Rovereto Hosp, Neurol Unit, Trento, Italy

[30] Univ Pavia, Dept Mol Med, Pavia, Italy

[31] IRCCS Mondino Fdn, Neurogenet Res Ctr, Pavia, Italy

[32] IRCCS Humanitas Res Hosp, Dept Neurol, Rozzano, Italy

[33] Moriggia Pelascini Hosp, Dept Parkinsons Dis Movement Disorders & Brain Inj, Gravedona, Italy

[34] Univ Padua, Dept Neurosci, Parkinson & Movement Disorders Unit, Ctr Neurodegenerat Dis CESNE, Padua, Italy

[35] ASST Fatebenefratelli Sacco, Neurol Dept, Milan, Italy

[36] Santa Maria Hosp, Dept Neurol, I-05100 Terni, Italy

[37] Parkinsons Dis Excellence Ctr, Dept Neurorehabil, Casa Cura Villa Margher Via Costacolonna 1, Arcugnano, Vicenza, Italy

[38] Univ Perugia, Perugia Gen Hosp, Movement Disorders Ctr, Neurol Dept, Perugia, Italy

[39] Brotzu Hosp, Dept Neurosci, Cagliari, Italy

[40] Univ Catania, Dept GF Ingrassia, Catania, Italy

来源：

MOVEMENT DISORDERS CLINICAL PRACTICE | 2024年 / 11卷 / 11期

关键词：

familial and sporadic Parkinson's disease; family history; hyposmia; cognitive impairment; depression; bipolar disorder; GBA MUTATIONS; RISK; EPIDEMIOLOGY; DISORDERS;

D O I：

10.1002/mdc3.14206

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect. Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD). Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected. Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group. Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

引用

页码：1434 / 1440

页数：7

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