BACKGROUND: Navigated transcranial magnetic stimulation (nTMS) is a well-established preoperative mapping tool for motor-eloquent glioma surgery. Machine learning (ML) and nTMS may improve clinical outcome prediction and histological correlation. METHODS: This was a retrospective cohort study of patients who underwent surgery for motor-eloquent gliomas between 2018 and 2022. Ten healthy subjects were included. Preoperative nTMS-derived variables were collected: resting motor threshold (RMT), interhemispheric RMT ratio (iRMTr)-abnormal if above 10%- and cortical excitability score-number of abnormal iRMTrs. World Health Organization (WHO) grade and molecular profile were collected to characterize each tumor. ML models were fitted to the data after statistical feature selection to predict tumor grade. RESULTS: A total of 177 patients were recruited: WHO grade 2-32 patients, WHO grade 3-65 patients, and WHO grade 4-80 patients. For the upper limb, abnormal iRMTr were identified in 22.7% of WHO grade 2, 62.5% of WHO grade 3, and 75.4% of WHO grade 4 patients. For the lower limb, iRMTr was abnormal in 23.1% of WHO grade 2, 67.6% of WHO grade 3%, and 63.6% of WHO grade 4 patients. Cortical excitability score (P = .04) was statistically significantly related with WHO grading. Using these variables as predictors, the ML model had an accuracy of 0.57 to predict WHO grade 4 lesions. In subgroup analysis of high-grade gliomas vs low-grade gliomas, the accuracy for high-grade gliomas prediction increased to 0.83. The inclusion of molecular data into the model-IDH mutation and 1p19q codeletion status-increases the accuracy of the model in predicting tumor grading (0.95 and 0.74, respectively). CONCLUSION: ML algorithms based on nTMS-derived interhemispheric excitability assessment provide accurate predictions of HGGs affecting the motor pathway. Their accuracy is further increased when molecular data are fitted onto the model paving the way for a joint preoperative approach with radiogenomics.
引用
收藏
页码:347 / 356
页数:10
相关论文
共 41 条
[1]
Bonsanto MM, 2020, CHIRURG, V91, P229, DOI 10.1007/s00104-020-01131-9
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Chen, Danni
;
Lei, Xu
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Lei, Xu
;
Du, Lian
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Du, Lian
;
Long, Zhiliang
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
机构:
Univ Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Chow, Daniel S.
;
Khatri, Deepak
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Neurosurg, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Khatri, Deepak
;
Chang, Peter D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Chang, Peter D.
;
Zlochower, Avraham
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Radiol, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Zlochower, Avraham
;
Boockvar, John A.
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Neurosurg, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Boockvar, John A.
;
Filippi, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Radiol, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Do, Yoon Ah
;
Cho, Se Jin
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Cho, Se Jin
;
Choi, Byung Se
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Choi, Byung Se
;
Baik, Sung Hyun
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Baik, Sung Hyun
;
Bae, Yun Jung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Bae, Yun Jung
;
Sunwoo, Leonard
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Sunwoo, Leonard
;
Jung, Cheolkyu
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Jung, Cheolkyu
;
Kim, Jae Hyoung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Hopman, H. J.
;
Chan, S. M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, G30 G-F Multictr,Tai Po Hosp 9 Chuen Rd, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chan, S. M. S.
;
Chu, W. C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Hosp, Rm 27023 G-F, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chu, W. C. W.
;
Lu, H.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Lu, H.
;
Tse, C-Y
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Sino Bldg,Rm 352,Chung Chi Rd, Hong Kong, Peoples R China
City Univ Hong Kong, Dept Social & Behav Sci, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Tse, C-Y
;
Chau, S. W. H.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Prince Wales Hosp, Jockey Club Sch Publ Hlth, 3-F Rm 327,30 Ngan Shing St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chau, S. W. H.
;
Lam, L. C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Lam, L. C. W.
;
Mak, A. D. P.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Mak, A. D. P.
;
Neggers, S. F. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Heidelberglaan 100, NL-3584 CX Utrecht, NetherlandsChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Chen, Danni
;
Lei, Xu
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Lei, Xu
;
Du, Lian
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Du, Lian
;
Long, Zhiliang
论文数: 0引用数: 0
h-index: 0
机构:
Southwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
Southwest Univ, Key Lab Cognit & Personal, Minist Educ, Chongqing, Peoples R ChinaSouthwest Univ, Fac Psychol, Sleep & NeuroImaging Ctr, Chongqing, Peoples R China
机构:
Univ Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Chow, Daniel S.
;
Khatri, Deepak
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Neurosurg, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Khatri, Deepak
;
Chang, Peter D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Chang, Peter D.
;
Zlochower, Avraham
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Radiol, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Zlochower, Avraham
;
Boockvar, John A.
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Neurosurg, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
Boockvar, John A.
;
Filippi, Christopher G.
论文数: 0引用数: 0
h-index: 0
机构:
Lenox Hill Hosp, Dept Radiol, Donald & Barbara Zucker Sch Med Hofstra Northwell, 100 East 77th St, New York, NY 10075 USAUniv Calif Irvine, Dept Radiol, Sch Med, Ctr Artificial Intelligence Diagnost Med CAIDM, 1001 Hlth Sci Rd, Orange, CA 92617 USA
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Do, Yoon Ah
;
Cho, Se Jin
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Cho, Se Jin
;
Choi, Byung Se
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Choi, Byung Se
;
Baik, Sung Hyun
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Baik, Sung Hyun
;
Bae, Yun Jung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Bae, Yun Jung
;
Sunwoo, Leonard
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Sunwoo, Leonard
;
Jung, Cheolkyu
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
Jung, Cheolkyu
;
Kim, Jae Hyoung
论文数: 0引用数: 0
h-index: 0
机构:
Seoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South KoreaSeoul Natl Univ Coll Med, Seoul Natl Univ Bundang Hosp, Dept Radiol, Seongnam, South Korea
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Hopman, H. J.
;
Chan, S. M. S.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, G30 G-F Multictr,Tai Po Hosp 9 Chuen Rd, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chan, S. M. S.
;
Chu, W. C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Prince Wales Hosp, Rm 27023 G-F, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chu, W. C. W.
;
Lu, H.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Lu, H.
;
Tse, C-Y
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Sino Bldg,Rm 352,Chung Chi Rd, Hong Kong, Peoples R China
City Univ Hong Kong, Dept Social & Behav Sci, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Tse, C-Y
;
Chau, S. W. H.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Prince Wales Hosp, Jockey Club Sch Publ Hlth, 3-F Rm 327,30 Ngan Shing St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Chau, S. W. H.
;
Lam, L. C. W.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Lam, L. C. W.
;
Mak, A. D. P.
论文数: 0引用数: 0
h-index: 0
机构:
Chinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R ChinaChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China
Mak, A. D. P.
;
Neggers, S. F. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Heidelberglaan 100, NL-3584 CX Utrecht, NetherlandsChinese Univ Hong Kong, Unit L,19-F Kings Wing Plaza 1,3 Kwan St, Hong Kong, Peoples R China