The real-world applicability of the 2023 international myelin oligodendrocyte glycoprotein antibody-associated disease criteria in a Latin American cohort

被引:0
作者
Contentti, Edgar Carnero [1 ]
Pestchanker, Claudia [2 ]
Ciampi, Ethel [3 ]
Suarez, Sheila Castro [4 ]
Zamalloa, Cesar Caparo [4 ]
Marques, Vanesa Daccach [5 ]
Messias, Katharina [5 ]
Gortari, Jose Ignacio [6 ]
Tkachuk, Veronica [6 ]
Silva, Berenice [7 ]
Mainella, Carolina [8 ]
Reyes, Saul [9 ,10 ,11 ]
Toro, Jaime [9 ,10 ]
Rodriguez, Juan [9 ,10 ]
Correa-Diaz, Edgar [12 ,13 ]
Rojas, Juan I. [14 ]
Paul, Friedemann [15 ,16 ,17 ,18 ,19 ,20 ]
机构
[1] Hosp Aleman, Dept Neurosci, Neuroimmunol Unit, Buenos Aires, Argentina
[2] Dr Ramon Carrillo Cent Hosp, Neurol Dept, San Luis, Argentina
[3] Univ Catolica Chile, Hosp Dr Sotero del Rio, Neurol Dept, Santiago, Chile
[4] Inst Nacl Ciencias Neurol, Basic Res Ctr Dementia & Cent Nervous Syst Demyeli, Lima, Peru
[5] Univ Sao Paulo, Hosp Clin, Fac Med Ribeirao Preto, Sao Paulo, Brazil
[6] Hosp Clin Buenos Aires, Neurol Dept, Buenos Aires, Argentina
[7] Hosp Italiano Buenos Aires, Neurol Dept, Buenos Aires, Argentina
[8] Hosp Espanol Rosario, Neurol Dept, Santa Fe, Argentina
[9] Fdn Santa Fe Bogota, Neurol Dept, Bogota, Colombia
[10] Univ Los Andes, Sch Med, Bogota, Colombia
[11] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London, England
[12] Hosp Carlos Andrade Marin, Dept Neurol, Quito, Ecuador
[13] Pontificia Univ Catolica Ecuador, Quito, Ecuador
[14] Ctr Esclerosis Multiple Buenos Aires, Neurol Dept, Buenos Aires, Argentina
[15] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany
[16] Free Univ Berlin, Berlin, Germany
[17] Humboldt Univ, Berlin, Germany
[18] Berlin Inst Hlth, Berlin, Germany
[19] Max Delbrueck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany
[20] Charite Univ Med Berlin, Berlin, Germany
关键词
diagnostic criteria; Latin America; MOGAD; optic neuritis; transverse myelitis; OPTIC-NERVE; DYNAMICS;
D O I
10.1111/ene.16445
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Purpose: The diagnostic criteria for myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) were published in 2023. We aimed to determine the performance of the new criteria in Latin American (LATAM) patients compared with the 2018 criteria and explore the significance of MOG-IgG titers in diagnosis. Methods: We retrospectively reviewed the medical records of LATAM (Argentina, Chile, Brazil, Peru, Ecuador, and Colombia) adult patients with one clinical MOGAD event and MOG-IgG positivity confirmed by cell-based assay. Both 2018 and 2023 MOGAD criteria were applied, calculating diagnostic performance indicators. Results: Among 171 patients (predominantly females, mean age at first attack = 34.1 years, mean disease duration = 4.5 years), 98.2% patients met the 2018 criteria, and of those who did not fulfill diagnostic criteria (n = 3), all tested positive for MOG-IgG (one low-positive and two without reported titer). Additionally, 144 (84.2%) patients met the 2023 criteria, of whom 57 (39.5%) had MOG-IgG+ titer information (19 clearly positive and 38 low-positive), whereas 87 (60.5%) patients had no MOG-IgG titer. All 144 patients met diagnostic supporting criteria. The remaining 27 patients did not meet the 2023 MOGAD criteria due to low MOG-IgG (n = 12) or lack of titer antibody access (n = 15), associated with the absence of supporting criteria. The 2023 MOGAD criteria showed a sensitivity of 86% (95% confidence interval = 0.80-0.91) and specificity of 100% compared to the 2018 criteria. Conclusions: These findings support the diagnostic utility of the 2023 MOGAD criteria in an LATAM cohort in real-world practice, despite limited access to MOG-IgG titration.
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页数:11
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