Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Overlap Syndrome An Update on the Epidemiology, Pathophysiology, and Management

被引：0

作者：

Nguyen, Benjamin H. M. ^{[1
,2
,3
,4
]}

Murphy, Patrick B. ^{[5
,6
]}

Yee, Brendon J. ^{[2
,4
]}

机构：

[1] St Vincents Hosp, Dept Thorac Med, Level 4,Xavier Bldg,390 Victoria St, Darlinghurst, NSW 2010, Australia

[2] Royal Prince Alfred Hosp, Dept Resp & Sleep Med, Level 11,Missenden Rd, Camperdown, NSW 2050, Australia

[3] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Sydney Med Sch Cent Sydney, Sydney, NSW 2006, Australia

[4] Macquarie Univ, Woolcock Inst Med Res, 2 Innovat Rd, Macquarie Pk, NSW 2113, Australia

[5] St Thomas Hosp, Guys & St Thomas NHS Fdn Trust, Lane Fox Resp Serv, Div Heart Lung & Crit Care, Ground Floor,South Wing,Westminster Bridge Rd, London SE1 7EH, England

[6] Kings Coll London, London WC2R 2LS, England

来源：

SLEEP MEDICINE CLINICS | 2024年 / 19卷 / 03期

关键词：

Comorbidity; Epidemiology; Exacerbations; Mortality; Management; Positive airway pressure therapy; POSITIVE AIRWAY PRESSURE; NEURAL RESPIRATORY DRIVE; PHYSICAL-ACTIVITY; AMERICAN ACADEMY; CARDIAC EVENTS; HEART-FAILURE; LUNG-VOLUME; COPD; MORTALITY; CPAP;

D O I：

10.1016/j.jsmc.2024.04.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

COPD-OSA OVS is common and confers significant increased cardiovascular morbidity and exacerbation risk. The driver of cardiovascular morbidity requires further work to elucidate the mechanism but appears in part driven by hypoxia and systemic inflammation. The ability of PAP therapy to attenuate these risks remains to be proven but it does appear to improve sleep symptoms in patients with OVS. There are a lack of guidelines on the management of OVS due to the paucity of good quality randomized controlled trials in this area and this should be the focus of future work. In particular, the ability of PAP therapy to reduce COPD exacerbations, hospitalization, and death, and whether there are clinically meaningful differences between CPAP or NIV in the management of patients with OVS needs further investigation.

引用

页码：405 / 417

页数：13

共 108 条

[1] Symptomatic response to CPAP in obstructive sleep apnea versus COPD- obstructive sleep apnea overlap syndrome: Insights from a large national registry [J].