Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils

被引：0

作者：

So, Masatomo ^{[1
,2
]}

Ono, Misaki ^{[3
]}

Oogai, Shigeki ^{[4
]}

Kondo, Minako ^{[5
]}

Yamazaki, Kaede ^{[4
]}

Nachtegael, Charlotte ^{[6
,7
]}

Hamajima, Hiroshi ^{[4
]}

Mutoh, Risa ^{[8
]}

Kato, Masaki ^{[3
,9
]}

Kawate, Hisaya ^{[3
,9
]}

Oki, Tomoyuki ^{[3
,9
]}

Kawata, Yasushi ^{[10
]}

Kumamoto, Shiho ^{[3
]}

Tokui, Noritaka ^{[3
,9
,11
]}

Takei, Toshiki

Shimizu, Kuniyoshi ^{[12
]}

Inoue, Akio ^{[13
]}

Yamamoto, Naoki ^{[14
]}

Unoki, Motoko ^{[15
]}

Tanabe, Kenichi ^{[3
,9
,11
]}

Nakashima, Kinichi ^{[16
]}

Sasaki, Hiroyuki ^{[17
]}

Hojo, Hironobu

Nagata, Yasuo ^{[4
]}

Suetake, Isao ^{[2
,3
,9
,11
,17
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Kyoto, Japan

[2] Osaka Univ, Inst Prot Res, Osaka, Japan

[3] Nakamura Gakuen Univ, Fac Nutr Sci, Dept Nutr Sci, Fukuoka, Japan

[4] Saga Prefectural Ind Innovat Ctr, Saga Food & Cosmet Lab, Saga, Japan

[5] Hamamatsu Univ, Sch Med, ARFS, Shizuoka, Japan

[6] Vrije Univ Brussel, Univ Libre Bruxelles, Interuniv Inst Bioinformat Brussels, Brussels, Belgium

[7] Univ Libre Bruxelles, Machine Learning Grp, Brussels, Belgium

[8] Fukuoka Univ, Fac Sci, Dept Appl Phys, Fukuoka, Japan

[9] Nakamura Gakuen Univ, Grad Sch Nutr Sci, Fukuoka, Japan

[10] Tottori Univ, Grad Sch Engn, Dept Chem & Biotechnol, Tottori, Japan

[11] Nakamura Gakuen Univ, Inst Prevent & Med Dietet, Fukuoka, Japan

[12] Kyushu Univ, Dept Agroenvironm Sci, Fukuoka, Japan

[13] Kyoto Univ, Human Brain Res Ctr, Grad Sch Med, Kyoto, Japan

[14] Univ Texas Southwestern Med Ctr, Dept Psychiat, Dallas, TX USA

[15] Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo, Japan

[16] Kyushu Univ, Grad Sch Med Sci, Dept Stem Cell Biol & Med, Fukuoka, Japan

[17] Kyushu Univ, Med Inst Bioregulat, Div Epigen & Dev, Fukuoka, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2024年 / 88卷 / 11期

关键词：

amyloid fibril formation; alpha-synuclein; eucalyptus; plant extracts; polyphenol; PROTEIN AGGREGATION; PARKINSONS-DISEASE; SUPERSATURATION; FIBRILLATION; MECHANISM; HYPOTHESIS; OLIGOMERS; CAPACITY; PEPTIDE; COMPETE;

D O I：

10.1093/bbb/zbae114

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of alpha-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of alpha-synuclein in the brain. Graphical Abstract Inhibitory effect of Eucalyptus gunnii extract on alpha-synuclein amyloid fibrils.

引用

页码：1289 / 1298

页数：10

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