High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis

被引：0

作者：

Bilek, Furkan ^{[1
]}

Ercan, Zubeyde ^{[2
]}

Deniz, Gulnihal ^{[3
]}

Ozgul, Sinem ^{[4
]}

Demir, Caner Feyzi ^{[5
]}

机构：

[1] Mugla Sitki Kocman Univ, Fethiye Fac Hlth Sci, Dept Gerontol, TR-48300 Mugla, Turkiye

[2] Firat Univ, Fac Hlth Sci, Dept Physiotherapy & Rehabil, Elazig, Turkiye

[3] Erzurum Tech Univ, Fac Hlth Sci, Dept Physiotherapy & Rehabil, Erzurum, Turkiye

[4] Firat Univ Hosp, Physiotherapy & Rehabil Clin, Elazig, Turkiye

[5] Firat Univ, Sch Med, Dept Neurol, Elazig, Turkiye

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2024年 / 395卷

关键词：

Multiple sclerosis; MMP-9; High-intensity interval exercise; Biomarker; MATRIX METALLOPROTEINASES; MMP-9; EXPRESSION; INFLAMMATION; INHIBITORS; YKL-40;

D O I：

10.1016/j.jneuroim.2024.578434

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.

引用

页数：7

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