Prognostic impact of Interleukin-8 levels in lung cancer: A meta-analysis and a bioinformatic validation

被引:1
|
作者
Belluomini, Lorenzo [1 ,2 ]
Incani, Ursula Cesta [1 ,2 ]
Smimmo, Annafrancesca [3 ]
Avancini, Alice [1 ,2 ,4 ]
Sposito, Marco [1 ,2 ]
Insolda, Jessica [1 ,2 ]
Scaglione, Ilaria Mariangela [1 ,2 ]
Gattazzo, Federica [5 ,6 ]
Caligola, Simone [7 ]
Adamo, Annalisa [8 ]
Conciatori, Fabiana [9 ]
Bazzichetto, Chiara [9 ]
Ugel, Stefano [8 ]
Giannarelli, Diana [10 ]
Pilotto, Sara [1 ,2 ]
Milella, Michele [1 ,2 ]
机构
[1] Univ Verona, Dept Engn Innovat Med DIMI, Sect Innovat Biomed, Oncol Area, Ple LA Scuro 10, I-37134 Verona, Italy
[2] Verona Univ Hosp Trust, Verona, Italy
[3] Univ Campania Luigi Vanvitelli, Med Stat Unit, Naples, Italy
[4] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy
[5] Univ Cattolica Sacro Cuore, Piacenza, Italy
[6] INSERM, U1015, Gustave Roussy Canc Campus, Villejuif, France
[7] IRCCS, Veneto Inst Oncol IOV, Padua, Italy
[8] Univ Verona, Dept Med, Sect Immunol, Verona, Italy
[9] IRCCS, Preclin Models & New Therapeut Agents Unit, Regina Elena Natl Canc Inst, Rome, Italy
[10] Fdn Policlin Univ Agostino Gemelli IRCCS, Comprehens Canc Ctr, Biostat Unit, Rome, Italy
关键词
Lung cancer; Interleukin-8; Biomarkers; Prognosis; REDUCED CLINICAL BENEFIT; SERUM INTERLEUKIN-8; SUPPRESSOR-CELLS; TUMOR; EXPRESSION; BIOMARKERS; RESISTANCE; CHEMOKINE; BLOCKADE; THERAPY;
D O I
10.1016/j.lungcan.2024.107893
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: High interleukin-8 (IL-8) levels have been linked to poor prognosis in lung cancer, but conclusive data are lacking. Materials and methods: A comprehensive search was conducted on April 1st, 2023, from electronic databases, focusing on studies with IL-8 expression evaluations and the availability of hazard ratio (HR) and 95% confidence intervals (CI) for overall survival (OS), progression-free survival (PFS) and disease-free survival (DFS) or adequate data for their estimation. Then, we examined IL-8 and CXCR1 RNA-seq data from The Cancer Genome Atlas (TCGA) dataset, and we correlated these data with OS. Results: Among 2655 produced records, 10 manuscripts involving both non-small cell lung cancer and small cell lung cancer, were included in the analysis. Two manuscripts and one study included two and three different cohorts, respectively, for a total of 14 cohorts of patients. Overall, 4 cohorts evaluated IL-8 levels in patients treated with chemotherapy, 3 cohorts immunotherapy, 2 cohorts surgical patients and 4 cohorts other treatments; 1 cohort was removed, as the type of treatments was lacking. The 12 cohorts included in the OS analysis revealed that patients with high IL-8 levels have a lower OS probability, as compared to patients with low IL-8 levels (HR=1.75, 95 % CI 1.36-2.26). No significant difference between patients with high and low IL-8 levels was observed in the 8 cohorts available for PFS analysis. Sensitivity analysis according to treatment revealed significant PFS and OS differences for patients treated with chemotherapy or immunotherapy. Analysis of RNAseq data from TCGA, confirmed the correlation between high IL-8 and CXCR1 expression and worse OS in patients with resected lung cancer.
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页数:9
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