Assessment of bidirectional impact of stigmatization induced self-medication on COVID-19 and malaria transmissions using mathematical modeling: Nigeria as a case study

被引：0

作者：

Avusuglo, Wisdom S. ^{[1
,2
,7
]}

Han, Qing ^{[1
,2
,5
,7
]}

Woldegerima, Woldegebriel Assefa ^{[1
,2
]}

Asgary, Ali ^{[1
,2
,7
]}

Wu, Jianhong ^{[1
,2
,7
]}

Orbinski, James ^{[1
,3
]}

Bragazzi, Nicola ^{[1
,2
]}

Ahmadi, Ali ^{[1
,4
]}

Kong, Jude Dzevela ^{[1
,5
,6
,7
]}

机构：

[1] York Univ, Africa Canada Artificial Intelligence & Data Innov, N York, ON, Canada

[2] York Univ, Dept Math & Stat, Lab Ind & Appl Math LIAM, N York, ON, Canada

[3] York Univ, Dahdaleh Inst Global Hlth Res, N York, ON, Canada

[4] KN Toosi Univ Technol, Fac Comp Engn, Tehran, Iran

[5] Univ Toronto, Dalla Lana Sch Publ Hlth, Artificial Intelligence & Math Modeling Lab AIMM L, 155 Coll St,Room 500, Toronto, ON M5T 3M7, Canada

[6] Univ Toronto, Bahen Ctr Informat Technol, Dept Math, Room 6291,40 St George St, Toronto, ON, Canada

[7] Global South Artificial Intelligence Pandem & Epid, Toronto, ON, Canada

来源：

MATHEMATICAL BIOSCIENCES | 2024年 / 376卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Mathematical modeling; COVID-19; Malaria; Co-dynamics; Self-medication; Stigmatization; Nigeria; SENSITIVITY-ANALYSIS; UNCERTAINTY;

D O I：

10.1016/j.mbs.2024.109249

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The continual social and economic impact of infectious diseases on nations has maintained sustained attention on their control and treatment, of which self-medication has been one of the means employed by some individuals. Self-medication complicates the attempt of their control and treatment as it conflicts with some of the measures implemented by health authorities. Added to these complications is the stigmatization of individuals with some diseases in some jurisdictions. This study investigates the co-infection of COVID-19 and malaria and its related deaths and further highlights how self-medication and stigmatization add to the complexities of the fight against these two diseases using Nigeria as a study case. Using a mathematical model on COVID-19 and malaria co-infection, we address the question: to what degree does the impact of the interaction between COVID-19 and malaria amplify infections and deaths induced by both diseases via self- medication and stigmatization? We demonstrate that COVID-19 related self-medication due to misdiagnoses contributes substantially to the prevalence of disease. The control reproduction numbers for these diseases and quantification of model parameters uncertainties and sensitivities are presented.

引用

页数：13

共 40 条

[1] Is Nigeria really on top of COVID-19? Message from effective reproduction number [J].