Host immune response against fungal biofilms

被引：5

作者：

Mannan, Mohammad ^{[1
]}

Nabeela, Sunna ^{[1
]}

Mishra, Reetakshi ^{[2
]}

Uppuluri, Priya ^{[1
,3
]}

机构：

[1] Harbor Univ Calif Angeles UCLA, Med Ctr, Lundquist Inst Biomed Innovat, Div Infect Dis, Torrance, CA 90095 USA

[2] Cypress High Sch, Cypress, CA USA

[3] UCLA, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2024年 / 81卷

基金：

美国国家卫生研究院;

关键词：

CRYPTOCOCCUS-NEOFORMANS; CANDIDA-ALBICANS; PLANKTONIC CELLS;

D O I：

10.1016/j.mib.2024.102520

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fungal biofilms are a multilayered community of cells attached to mucosal or abiotic surfaces enclosed in a coating of self-produced extracellular polymeric matrix. The sheer density of cells protected by a polymeric shield not only makes the biofilm impermeable to antimicrobials or immune cells but also hidden from host recognition. Biofilms also serve as a reservoir of drug-resistant persister cells and dispersal cells armored with virulence factors adept at evading the immune system. Here, we summarize the latest knowledge on the immunomodulatory properties of biofilms formed by Candida species and by other biofilm-forming fungal pathogens such as Aspergillus and Cryptococcus. Finally, we deliberate on promising strategies to help activate the immune system for combating fungal biofilms.

引用

页数：7

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