Automatic assessment of body composition in children with lymphoma: results of a [18F]FDG-PET/MR study

ObjectivesTo use Dixon-MR images extracted from [18F]FDG-PET/MR scans to perform an automatic, volumetric segmentation and quantification of body composition in pediatric patients with lymphoma. Materials and methodsPediatric patients with lymphoma examined by [F-18]FDG-PET/MR at diagnosis and restaging were included. At each time point, axial fat and water Dixon T1w images of the thighs were automatically segmented and muscle volume, subcutaneous, intramuscular, and intermuscular fat volume were quantified. The metabolic activity of the largest nodal lesion and of muscles and subcutaneous fat was recorded. The paired samples t-test and Spearman's correlation coefficient were applied to evaluate potential differences between the two time points and the relationship between metabolic and body composition metrics, respectively. By logistic regression analysis, the prognostic role of the investigated variables was assessed. The applied significance level was p < 0.05 for all analyses. ResultsThirty-seven patients (mean age +/- SD 14 +/- 3-years-old; 20 females) matched the inclusion criteria. After chemotherapy (interval between the two PET/MR scans, 56-80 days; median 65 days), muscle volume significantly decreased (629 +/- 259 cm3 vs 567 +/- 243 cm(3), p < 0.001) while subcutaneous, intramuscular and intermuscular fat increased (476 +/- 255 cm(3) vs 607 +/- 254 cm(3), p < 0.001; 63 +/- 20 cm(3) vs 76 +/- 26 cm(3), p < 0.001; 58 +/- 19 cm(3) vs 71 +/- 23 cm(3), p < 0.001); the metabolic activity of the main nodal lesion, muscles, and subcutaneous fat significantly decreased (p < 0.05, each). None of the examined variables acted as predictors of the response to treatment (p = 0.283). A strong correlation between BMI and subcutaneous fat volume at diagnosis (r = 0.675, p < 0.001) and restaging (r = 0.600, p < 0.001) emerged. ConclusionsThe proposed method demonstrated that pediatric patients with lymphoma undergo muscle loss and an increase of subcutaneous fat during treatment. Clinical relevance statementThe proposed automatic and volumetric MR-based assessment of body composition in children with lymphoma can be used to monitor the effect of chemotherapy and may guide tailored exercise programs during chemotherapy. Key Points...