Correlation of Noninvasive Cardiac MRI Measures of Left Ventricular Myocardial Function and Invasive Pressure-Volume Parameters in a Porcine Ischemia-Reperfusion Model

被引:0
作者
Deshmukh, Tejas [1 ,2 ,3 ]
Selvakumar, Dinesh [1 ,2 ,3 ]
Thavapalachandran, Sujitha [1 ,2 ,3 ]
Archer, Oliver [2 ]
Figtree, Gemma A. [4 ,5 ]
Feneley, Michael [6 ,7 ]
Grieve, Stuart M. [8 ,9 ]
Thomas, Liza [2 ,3 ]
Pathan, Faraz [10 ,11 ]
Chong, James J. H. [1 ,2 ,3 ]
机构
[1] Westmead Inst Med Res, Ctr Heart Res, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia
[2] Westmead Hosp, Dept Cardiol, Westmead, Australia
[3] Univ Sydney, Fac Med & Hlth, Sydney Sch Hlth Sci, Sydney, Australia
[4] Univ Sydney, Kolling Inst, Cardiovasc Discovery Grp, Sydney, Australia
[5] Royal North Shore Hosp, Sydney, Australia
[6] St Vincents Hosp, Dept Cardiol, Darlinghurst, Australia
[7] Victor Chang Cardiac Res Inst, Cardiac Mech Lab, Darlinghurst, Australia
[8] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Imaging & Phenotyping Lab, Sydney, Australia
[9] Royal Prince Alfred Hosp, Dept Radiol, Camperdown, Australia
[10] Univ Sydney, Charles Perkin Ctr Nepean, Nepean Clin Sch Med, Kingswood, Australia
[11] Nepean Hosp, Dept Cardiol, Kingswood, Australia
基金
英国医学研究理事会;
关键词
Cardiac MRI; Myocardial Infarction; Pressure Volume Loop; Strain Imaging; Ventriculo-arterial Coupling; GLOBAL LONGITUDINAL STRAIN; SINGLE-BEAT DETERMINATION; MAGNETIC-RESONANCE; EJECTION FRACTION; SYSTOLIC FUNCTION; PROGNOSTIC VALUE; HEART-FAILURE; ECHOCARDIOGRAPHY; ENHANCEMENT;
D O I
10.1148/ryct.230252
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To assess the correlation between noninvasive cardiac MRI-derived parameters with pressure-volume (PV) loop data and evaluate changes in left ventricular function after myocardial infarction (MI). Materials and Methods: Sixteen adult female swine were induced with MI, with six swine used as controls and 10 receiving platelet-derived growth factor-AB (PDGF-AB). Load-independent measures of cardiac function, including slopes of end-systolic pressure-volume relationship (ESPVR) and preload recruitable stroke work (PRSW), were obtained on day 28 after MI. Cardiac MRI was performed on day 2 and day 28 after infarct. Global longitudinal strain (GLS) and global circumferential strain (GCS) were measured. Ventriculo-arterial coupling (VAC) was derived from PV loop and cardiac MRI data. Pearson correlation analysis was performed. Results: GCS ( r = 0.60, P = .01), left ventricular ejection fraction (LVEF) ( r = 0.60, P = .01), and cardiac MRI-derived VAC ( r = 0.61, P = .01) had a significant linear relationship with ESPVR. GCS ( r = 0.75, P < .001) had the strongest significant linear relationship with PRSW, followed by LVEF ( r = 0.67, P = .005) and cardiac MRI-derived VAC ( r = 0.60, P = .01). GLS was not significantly correlated with ESPVR or PRSW. There was a linear correlation ( r = 0.82, P < .001) between VAC derived from cardiac MRI and from PV loop data. GCS (-3.5% +/- 2.3 vs 0.5% +/- 1.4, P = .007) and cardiac MRI-derived VAC (-0.6 +/- 0.6 vs 0.3 +/- 0.3, P = .001) significantly improved in the animals treated with PDGF-AB 28 days after MI compared with controls. Conclusion: Cardiac MRI-derived parameters of MI correlated with invasive PV measures, with GCS showing the strongest correlation. Cardiac MRI-derived measures also demonstrated utility in assessing therapeutic benefit using PDGF-AB.
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页数:9
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