Multiorgan Toxicity from Dual Checkpoint Inhibitor Therapy, Resulting in a Complete Response-A Case Report

被引：3

作者：

Astasauskaite, Skaiste ^{[1
]}

Kupcinskaite-Noreikiene, Rita ^{[1
]}

Zaboriene, Inga ^{[2
]}

Vaiciuniene, Ruta ^{[3
]}

Vanagas, Tomas ^{[4
]}

Pranys, Darius ^{[5
]}

Poskiene, Lina ^{[5
]}

Juozaityte, Elona ^{[1
]}

机构：

[1] Lithuanian Univ Hlth Sci, Inst Oncol, Med Acad, Fac Med, LT-50161 Kaunas, Lithuania

[2] Lithuanian Univ Hlth Sci, Med Acad, Fac Med, Dept Radiol, LT-50161 Kaunas, Lithuania

[3] Lithuanian Univ Hlth Sci, Med Acad, Fac Med, Dept Nephrol, LT-50161 Kaunas, Lithuania

[4] Lithuanian Univ Hlth Sci, Med Acad, Fac Med, Dept Surg, LT-50161 Kaunas, Lithuania

[5] Lithuanian Univ Hlth Sci, Med Acad, Fac Med, Dept Pathol, LT-50161 Kaunas, Lithuania

来源：

MEDICINA-LITHUANIA | 2024年 / 60卷 / 07期

关键词：

immune checkpoint inhibitors; immune checkpoint inhibitor-induced colitis; immune-mediated nephritis; immune checkpoint inhibitor-induced hepatitis; clear cell renal carcinoma; complete response; CANCER; RISK;

D O I：

10.3390/medicina60071129

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunotherapy treatment with checkpoint inhibitors (ICIs) has led to a breakthrough in the treatment of oncological diseases. Despite its clinical effectiveness, this treatment differs from others, such as cytotoxic chemotherapy, in that it causes immune-related adverse events. This type of toxicity can affect any organ or organ system of the body. We present a literature review and a rare clinical case from our clinical practice, in which a patient with metastatic clear cell renal carcinoma was treated with a single dose of dual checkpoint blockade (cytotoxic T-lymphocyte-4 (CTLA-4) and programmed death-1 (PD-1)) and simultaneously diagnosed with colitis, hepatitis, and nephritis. After early immunosuppressive treatment with the glucocorticoids, complete organ function recovery was achieved. The follow-up revealed a sustained complete response lasting more than a year.

引用

页数：8

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