Tumor Microenvironment-Derived Exosomes: A Double-Edged Sword for Advanced T Cell-Based Immunotherapy

被引:7
作者
Lu, Ye [1 ]
Zheng, Jiarong [2 ]
Lin, Pei [1 ]
Lin, Yunfan [1 ]
Zheng, Yucheng [1 ]
Mai, Zizhao [1 ]
Chen, Xu [1 ]
Xia, Tian [3 ]
Zhao, Xinyuan [1 ]
Cui, Li [1 ,4 ]
机构
[1] Southern Med Univ, Stomatol Hosp, Sch Stomatol, Guangzhou 510280, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dent, Guangzhou 510080, Peoples R China
[3] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA
基金
中国国家自然科学基金;
关键词
Tumor microenvironment; Immune evasion; Therapeutictarget; Nanocarrier; Exosomes; T cell; Immune response; Immunotherapy; CD8(+) CTL RESPONSES; DENDRITIC CELLS; ANTITUMOR IMMUNITY; CANCER-CELLS; INDUCTION; ANTIGEN; GENE; SUPPRESSION; PROGRESSION; MICRORNAS;
D O I
10.1021/acsnano.4c09190
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The tumor microenvironment (TME) plays a crucial role in cancer progression and immune evasion, partially mediated by the activity of the TME-derived exosomes. These extracellular vesicles are pivotal in shaping immune responses through the transfer of proteins, lipids, and nucleic acids between cells, facilitating a complex interplay that promotes tumor growth and metastasis. This review delves into the dual roles of exosomes in the TME, highlighting both their immunosuppressive functions and their emerging therapeutic potential. Exosomes can inhibit T cell function and promote tumor immune escape by carrying immune-modulatory molecules, such as PD-L1, yet they also hold promise for cancer therapy as vehicles for delivering tumor antigens and costimulatory signals. Additionally, the review discusses the intricate crosstalk mediated by exosomes among various cell types within the TME, influencing both cancer progression and responses to immunotherapies. Moreover, this highlights current challenges and future directions. Collectively, elucidating the detailed mechanisms by which TME-derived exosomes mediate T cell function offers a promising avenue for revolutionizing cancer treatment. Understanding these interactions allows for the development of targeted therapies that manipulate exosomal pathways to enhance the immune system's response to tumors.
引用
收藏
页码:27230 / 27260
页数:31
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