Natural Compounds for Preventing Age-Related Diseases and Cancers

被引:11
作者
Ki, Mi-Ran [1 ,2 ]
Youn, Sol [1 ]
Kim, Dong Hyun [1 ]
Pack, Seung Pil [1 ]
机构
[1] Korea Univ, Dept Biotechnol & Bioinformat, Sejong Ro 2511, Sejong 30019, South Korea
[2] Korea Univ, Inst Ind Technol, Sejong ro 2511, Sejong 30019, South Korea
基金
新加坡国家研究基金会;
关键词
natural compounds; aging; age-related diseases; cancer; autophagy; circadian rhythms; TO-MESENCHYMAL TRANSITION; CELL-CYCLE ARREST; PROSTATE-CANCER; GASTRIC-CANCER; COLORECTAL-CANCER; RISK-FACTORS; CIRCADIAN CLOCK; BREAST-CANCER; COLON-CANCER; HEPATOCELLULAR-CARCINOMA;
D O I
10.3390/ijms25147530
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external and internal signs of aging manifest in various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. Additionally, cancer, like aging, is a complex disease that arises from the accumulation of various genetic and epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for aging and cancer development. Natural compounds and herbal medicines have gained significant attention for their potential in preventing age-related diseases and inhibiting cancer progression. These compounds demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects as well as circadian clock regulation. This review explores age-related diseases, cancers, and the potential of specific natural compounds in targeting the key features of these conditions.
引用
收藏
页数:58
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