Novel drug delivery systems in colorectal cancer: Advances and future prospects

被引:2
作者
Kamal, Raj [1 ,2 ]
Awasthi, Ankit [3 ,4 ]
Paul, Priyanka [5 ]
Mir, Mohammad Shabab [2 ]
Singh, Sachin Kumar [6 ,7 ]
Dua, Kamal [7 ,8 ]
机构
[1] ISF Coll Pharm, Dept Qual Assurance, Moga 142001, Punjab, India
[2] Desh Bhagat Univ, Sch Pharm, Mandi Gobindgarh 147301, Punjab, India
[3] ISF Coll Pharm, Dept Pharmaceut, Moga 142001, Punjab, India
[4] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India
[5] PCTE Grp Inst, Dept Pharmaceut Sci, Ludhiana, Punjab, India
[6] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India
[7] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia
[8] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia
关键词
Colorectal cancer; Biomarkers; Signaling pathways; NDDS; Clinical trials; Patents; COLON-CANCER; SIGNALING PATHWAY; PI3K/AKT/MTOR PATHWAY; THERAPEUTIC-EFFICACY; OXIDE NANOPARTICLES; CELL-PROLIFERATION; MISMATCH REPAIR; NITRIC-OXIDE; TUMOR-GROWTH; IN-VITRO;
D O I
10.1016/j.prp.2024.155546
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Colorectal cancer (CRC) is an abnormal proliferation of cells within the colon and rectum, leading to the formation of polyps and disruption of mucosal functions. The disease development is influenced by a combination of factors, including inflammation, exposure to environmental mutagens, genetic alterations, and impairment in signaling pathways. Traditional treatments such as surgery, radiation, and chemotherapy are often used but have limitations, including poor solubility and permeability, treatment resistance, side effects, and post-surgery issues. Novel Drug Delivery Systems (NDDS) have emerged as a superior alternative, offering enhanced drug solubility, precision in targeting cancer cells, and regulated drug release. Thereby addressing the shortcomings of conventional therapies and showing promise for more effective CRC management. The present review sheds light on the pathogenesis, signaling pathways, biomarkers, conventional treatments, need for NDDS, and application of NDDS against CRC. Additionally, clinical trials, ongoing clinical trials, marketed formulations, and patents on CRC are also covered in the present review.
引用
收藏
页数:29
相关论文
共 384 条
[1]   Chemical investigation and screening of anti-cancer potential of Syzygium aromaticum L. bud (clove) essential oil nanoemulsion [J].
Abadi, Atena Vafaei Malek ;
Karimi, Ehsan ;
Oskoueian, Ehsan ;
Mohammad, Ghasem Rahimi Kalateh Shah ;
Shafaei, Negin .
3 BIOTECH, 2022, 12 (02)
[2]   Comparative therapeutic effects of Pituranthos tortuosus aqueous extract and phyto-synthesized gold nanoparticles on Helicobacter pylori, diabetic and cancer proliferation [J].
Abd El-Moaty, Heba Ibrahim ;
Soliman, Nadia A. ;
Hamad, Rabab S. ;
Ismail, Eman H. ;
Sabry, Dina Y. ;
Khalil, Mostafa M. H. .
SOUTH AFRICAN JOURNAL OF BOTANY, 2021, 139 :167-174
[3]   Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review [J].
Abdulridha, Manal Khalid ;
Al-Marzoqi, Ali H. ;
Al-Awsi, Ghaidaa Raheem Lateef ;
Mubarak, Shaden M. H. ;
Heidarifard, Maryam ;
Ghasemian, Abdolmajid .
JOURNAL OF GASTROINTESTINAL CANCER, 2020, 51 (03) :765-773
[4]   The Anticancer Efficiency of Citrullus colocynthis Toward the Colorectal Cancer Therapy [J].
Abdulridha, Manal Khalid ;
Al-Marzoqi, Ali-H ;
Ghasemian, Abdolmajid .
JOURNAL OF GASTROINTESTINAL CANCER, 2020, 51 (02) :439-444
[5]   Targeted delivery of oxaliplatin via folate-decorated niosomal nanoparticles potentiates resistance reversion of colon cancer cells [J].
Abdulzehra, Siham ;
Jafari-Gharabaghlou, Davoud ;
Zarghami, Nosratollah .
HELIYON, 2023, 9 (11)
[6]   An improved method in fabrication of smart dual-responsive nanogels for controlled release of doxorubicin and curcumin in HT-29 colon cancer cells [J].
Abedi, Fatemeh ;
Davaran, Soodabeh ;
Hekmati, Malak ;
Akbarzadeh, Abolfazl ;
Baradaran, Behzad ;
Moghaddam, Sevil Vaghefi .
JOURNAL OF NANOBIOTECHNOLOGY, 2021, 19 (01)
[7]   THE EVOLUTION OF RADIATION THERAPY IN TREATING CANCER [J].
Abshire, Dorothy ;
Lang, Matthew K. .
SEMINARS IN ONCOLOGY NURSING, 2018, 34 (02) :151-157
[8]   Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives [J].
Aghabozorgi, Amirsaeed Sabeti ;
Bahreyni, Amirhossein ;
Soleimani, Atena ;
Bahrami, Afsane ;
Khazaei, Majid ;
Ferns, Gordon A. ;
Avan, Amir ;
Hassanian, Seyed Mahdi .
BIOCHIMIE, 2019, 157 :64-71
[9]   A novel 5-Fluorocuracil multiple-nanoemulsion used for the enhancement of oral bioavailability in the treatment of colorectal cancer [J].
Ahmad, Niyaz ;
Albassam, Ahmed A. ;
Khan, Mohd Faiyaz ;
Ullah, Zabih ;
Buheazah, Taysser Mohammed ;
AlHomoud, Hussain Salman ;
Al-Nasif, Hassan Ali .
SAUDI JOURNAL OF BIOLOGICAL SCIENCES, 2022, 29 (05) :3704-3716
[10]   MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies [J].
Ahmadi, Seyed Esmaeil ;
Rahimi, Samira ;
Zarandi, Bahman ;
Chegeni, Rouzbeh ;
Safa, Majid .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 14 (01)