The cellular RNA-dependent RNA polymerases in plants

被引：2

作者：

Du, Xuan ^{[1
]}

机构：

[1] Shenzhen Univ, Coll Life Sci & Oceanog, Guangdong Prov Key Lab Plant Epigenet, Shenzhen 518060, Peoples R China

来源：

NEW PHYTOLOGIST | 2024年 / 244卷 / 06期

关键词：

gene silencing; molecular mechanisms; plants; pre-siRNA biosynthesis; RNA-dependent RNA polymerase; DIRECTED DNA METHYLATION; POL IV; CENTRAL DOGMA; TRANSCRIPTION; RDR2; ESTABLISHMENT; MAINTENANCE; PROTEINS; MAIZE; SITES;

D O I：

10.1111/nph.20046

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

RNA-dependent RNA Polymerases (RdRPs) synthesize double-stranded RNA (dsRNA) from a single-stranded RNA (ssRNA) template. In plants, dsRNAs produced by RdRPs can be further processed into small interfering RNA (siRNAs) with different lengths, ranging from 21 to 24 nucleotides (nt). These siRNAs play a pivotal role in various biological processes, including antiviral responses, transposable elements silencing, DNA methylation, and the regulation of plant reproduction and development. Recent research has reported significant progress in uncovering the molecular mechanisms of plant RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), a representative RdRP involved in the RNA-directed DNA methylation (RdDM) pathway. These discoveries provide a molecular basis underlying the principles of RdRP function and offer insights into potential advancements in crop breeding and antiviral defense strategies.

引用

页码：2150 / 2155

页数：6

共 45 条

[1] Phylogenetic analyses of seven protein families refine the evolution of small RNA pathways in green plants [J].

Belanger, Sebastien ;

Zhan, Junpeng ;

Meyers, Blake C. .

PLANT PHYSIOLOGY, 2023, 192 (02) :1183-1203

[2] Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis [J].

Blevins, Todd ;

Podicheti, Ram ;

Mishra, Vibhor ;

Marasco, Michelle ;

Wang, Jing ;

Rusch, Doug ;

Tang, Haixu ;

Pikaard, Craig S. .

ELIFE, 2015, 4

[3] The expanding world of small RNAs in plants [J].

Borges, Filipe ;

Martienssen, Robert A. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (12) :727-741

[4] A Medicago truncatula rdr6 allele impairs transgene silencing and endogenous phased siRNA production but not development [J].

Bustos-Sanmamed, Pilar ;

Hudik, Elodie ;

Laffont, Carole ;

Reynes, Christelle ;

Sallet, Erika ;

Wen, Jiangqi ;

Mysore, Kirankumar S. ;

Camproux, Anne-Claude ;

Hartmann, Caroline ;

Gouzy, Jerome ;

Frugier, Florian ;

Crespi, Martin ;

Lelandais-Briere, Christine .

PLANT BIOTECHNOLOGY JOURNAL, 2014, 12 (09) :1308-1318

[5] Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis [J].

Cao, Mengji ;

Du, Peng ;

Wang, Xianbing ;

Yu, Yun-Qi ;

Qiu, Yan-Hong ;

Li, Wanxiang ;

Gal-On, Amit ;

Zhou, Changyong ;

Li, Yi ;

Ding, Shou-Wei .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (40) :14613-14618

[6] Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing [J].

Chang, Howard Y. ;

Qi, Lei S. .

MOLECULAR CELL, 2023, 83 (03) :442-451

[7] Structural basis of transcription:: RNA polymerase II at 2.8 Ångstrom resolution [J].

Cramer, P ;

Bushnell, DA ;

Kornberg, RD .

SCIENCE, 2001, 292 (5523) :1863-1876

[8] CENTRAL DOGMA OF MOLECULAR BIOLOGY [J].

CRICK, F .

NATURE, 1970, 227 (5258) :561-&

[9] Origin and Evolution of RNA-Dependent RNA Polymerase [J].

de Farias, Savio T. ;

Junior, Ariosvaldo P. dos Santos ;

Rego, Thais G. ;

Jose, Marco V. .

FRONTIERS IN GENETICS, 2017, 8

[10] Primer-Dependent and Primer-Independent Initiation of Double Stranded RNA Synthesis by Purified Arabidopsis RNA-Dependent RNA Polymerases RDR2 and RDR6 [J].

Devert, Anthony ;

Fabre, Nicolas ;

Floris, Maina ;

Canard, Bruno ;

Robaglia, Christophe ;

Crete, Patrice .

PLOS ONE, 2015, 10 (03)

← 1 2 3 4 5 →