Advances in macrophage-derived exosomes as immunomodulators in disease progression and therapy

被引：4

作者：

Chen, Huizhu ^{[1
,2
,3
]}

Han, Ziping ^{[4
,5
]}

Ma, Yong ^{[1
,3
]}

Meng, Qingyang ^{[1
,3
]}

机构：

[1] Peking Univ, Peking Univ Third Hosp, Dept Sports Med,Inst Sports Med, Beijing Key Lab Sports Injuries, Beijing 100191, Peoples R China

[2] Peking Univ, Hosp 1, Hlth Sci Ctr, Beijing 100034, Peoples R China

[3] Minist Educ, Engn Res Ctr Sports Trauma Treatment Technol & Dev, Beijing 100191, Peoples R China

[4] Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing, Peoples R China

[5] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 142卷

关键词：

Exosomes; Macrophage; Immunomodulation; EXTRACELLULAR VESICLES; POLARIZATION; CANCER; ACTIVATION; BREAST; CONTRIBUTES; CARCINOMA; MICRORNA; PROMOTES; INVASION;

D O I：

10.1016/j.intimp.2024.113248

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Most somatic cells secrete vesicles called exosomes, which contain a variety of biomolecules. Recent research indicates that macrophage-derived exosomes are strongly correlated with tumors, infectious diseases, chronic inflammation, and tissue fibrosis. Therefore, the purpose of this review is to delve into the mechanisms of pathological states and how macrophage-derived exosomes react to them. We also discuss the biological effects of exosomes and how they affect disease. In addition, we have examined the possible uses of exosomes in illness treatment, highlighting both the benefits and drawbacks of these applications.

引用

页数：11

共 112 条

[1]

Alvero A.B., 2023, Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory, DOI [10.1101/2023.09.27.559828, DOI 10.1101/2023.09.27.559828]

[2] Ultrasound Facilitates Naturally Equipped Exosomes Derived from Macrophages and Blood Serum for Orthotopic Glioma Treatment [J].