Role of Carbon, Nitrogen, Phosphate and Sulfur Metabolism in Secondary Metabolism Precursor Supply in Streptomyces spp.

被引:3
作者
Krysenko, Sergii [1 ,2 ]
Wohlleben, Wolfgang [1 ,2 ,3 ]
机构
[1] Univ Tubingen, Interfac Inst Microbiol & Infect Med Tubingen IMIT, Dept Microbiol Biotechnol, Morgenstelle 28, D-72076 Tubingen, Germany
[2] Univ Tubingen, Cluster Excellence Controlling Microbes Fight Infe, D-72076 Tubingen, Germany
[3] German Ctr Infect Res DZ, Partner Site Tubingen, D-72076 Tubingen, Germany
关键词
primary metabolism; secondary metabolism; Streptomyces; bacterial physiology; precursor supply; BIOSYNTHETIC GENE-CLUSTER; ANTIBIOTIC PRODUCTION; IN-VIVO; COELICOLOR A3(2); GLUCOSE KINASE; ACID; PHOP; IDENTIFICATION; REGULATORS; EVOLUTION;
D O I
10.3390/microorganisms12081571
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The natural soil environment of Streptomyces is characterized by variations in the availability of nitrogen, carbon, phosphate and sulfur, leading to complex primary and secondary metabolisms. Their remarkable ability to adapt to fluctuating nutrient conditions is possible through the utilization of a large amount of substrates by diverse intracellular and extracellular enzymes. Thus, Streptomyces fulfill an important ecological role in soil environments, metabolizing the remains of other organisms. In order to survive under changing conditions in their natural habitats, they have the possibility to fall back on specialized enzymes to utilize diverse nutrients and supply compounds from primary metabolism as precursors for secondary metabolite production. We aimed to summarize the knowledge on the C-, N-, P- and S-metabolisms in the genus Streptomyces as a source of building blocks for the production of antibiotics and other relevant compounds.
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页数:20
相关论文
共 117 条
[1]   Streptomyces: The biofactory of secondary metabolites [J].
Alam, Khorshed ;
Mazumder, Arpita ;
Sikdar, Suranjana ;
Zhao, Yi-Ming ;
Hao, Jinfang ;
Song, Chaoyi ;
Wang, Yanyan ;
Sarkar, Rajib ;
Islam, Saiful ;
Zhang, Youming ;
Li, Aiying .
FRONTIERS IN MICROBIOLOGY, 2022, 13
[2]   Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets [J].
Allenby, Nicholas E. E. ;
Laing, Emma ;
Bucca, Giselda ;
Kierzek, Andrzej M. ;
Smith, Colin P. .
NUCLEIC ACIDS RESEARCH, 2012, 40 (19) :9543-9556
[3]   The role of antibiotics and antibiotic resistance in nature [J].
Aminov, Rustam I. .
ENVIRONMENTAL MICROBIOLOGY, 2009, 11 (12) :2970-2988
[4]   Harnessing regulatory networks in Actinobacteria for natural product discovery [J].
Augustijn, Hannah E. ;
Roseboom, Anna M. ;
Medema, Marnix H. ;
van Wezel, Gilles P. .
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2024, 51
[5]   Gifted microbes for genome mining and natural product discovery [J].
Baltz, Richard H. .
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2017, 44 (4-5) :573-588
[6]   Identification of a cluster of genes that directs desferrioxamine biosynthesis in Streptomyces coelicolor M145 [J].
Barona-Gómez, F ;
Wong, U ;
Giannakopulos, AE ;
Derrick, PJ ;
Challis, GL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (50) :16282-16283
[7]   OVEREXPRESSION OF A STREPTOMYCES-VIRIDOCHROMOGENES GENE (GLNII) ENCODING A GLUTAMINE-SYNTHETASE SIMILAR TO THOSE OF EUKARYOTES CONFERS RESISTANCE AGAINST THE ANTIBIOTIC PHOSPHINOTHRICYL-ALANYL-ALANINE [J].
BEHRMANN, I ;
HILLEMANN, D ;
PUHLER, A ;
STRAUCH, E ;
WOHLLEBEN, W .
JOURNAL OF BACTERIOLOGY, 1990, 172 (09) :5326-5334
[8]   Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].
Bentley, SD ;
Chater, KF ;
Cerdeño-Tárraga, AM ;
Challis, GL ;
Thomson, NR ;
James, KD ;
Harris, DE ;
Quail, MA ;
Kieser, H ;
Harper, D ;
Bateman, A ;
Brown, S ;
Chandra, G ;
Chen, CW ;
Collins, M ;
Cronin, A ;
Fraser, A ;
Goble, A ;
Hidalgo, J ;
Hornsby, T ;
Howarth, S ;
Huang, CH ;
Kieser, T ;
Larke, L ;
Murphy, L ;
Oliver, K ;
O'Neil, S ;
Rabbinowitsch, E ;
Rajandream, MA ;
Rutherford, K ;
Rutter, S ;
Seeger, K ;
Saunders, D ;
Sharp, S ;
Squares, R ;
Squares, S ;
Taylor, K ;
Warren, T ;
Wietzorrek, A ;
Woodward, J ;
Barrell, BG ;
Parkhill, J ;
Hopwood, DA .
NATURE, 2002, 417 (6885) :141-147
[9]  
Bhave Devayani P., 2007, Infectious Disorders - Drug Targets, V7, P140
[10]   Bursts in biosynthetic gene cluster transcription are accompanied by surges of natural compound production in the myxobacterium Sorangium sp. [J].
Boldt, Judith ;
Lukoseviciute, Laima ;
Fu, Chengzhang ;
Steglich, Matthias ;
Bunk, Boyke ;
Junker, Vera ;
Gollasch, Aileen ;
Trunkwalter, Birte ;
Mohr, Kathrin I. ;
Beckstette, Michael ;
Wink, Joachim ;
Overmann, Joerg ;
Mueller, Rolf ;
Nuebel, Ulrich .
MICROBIAL BIOTECHNOLOGY, 2023, 16 (05) :1054-1068