Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.
机构:
Oregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Barneck, Mitchell D.
;
Rhodes, Nathaniel L. R.
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Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Rhodes, Nathaniel L. R.
;
de la Presa, Martin
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h-index: 0
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Univ Utah, Sch Med, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
de la Presa, Martin
;
Allen, James P.
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h-index: 0
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Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Allen, James P.
;
Poursaid, Ahrash E.
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h-index: 0
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Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Poursaid, Ahrash E.
;
Nourian, Maziar M.
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h-index: 0
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Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Nourian, Maziar M.
;
Firpo, Matthew A.
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h-index: 0
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Univ Utah, Dept Surg, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Firpo, Matthew A.
;
Langell, John T.
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h-index: 0
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Univ Utah, Dept Surg, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Dai, Tianhong
;
Huang, Ying-Ying
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h-index: 0
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USA
Guangxi Med Univ, Aesthet & Plast Ctr, Nanning, Peoples R ChinaMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Huang, Ying-Ying
;
Hamblin, Michael R.
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h-index: 0
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USA
Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
机构:
Oregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Barneck, Mitchell D.
;
Rhodes, Nathaniel L. R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Rhodes, Nathaniel L. R.
;
de la Presa, Martin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
de la Presa, Martin
;
Allen, James P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Allen, James P.
;
Poursaid, Ahrash E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Poursaid, Ahrash E.
;
Nourian, Maziar M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Hlth Sci, Ctr Med Innovat, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Nourian, Maziar M.
;
Firpo, Matthew A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
Firpo, Matthew A.
;
Langell, John T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Salt Lake City, UT USAOregon Hlth & Sci Univ, Sch Med, 3239 SW Nebraska St, Portland, OR 97239 USA
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Dai, Tianhong
;
Huang, Ying-Ying
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USA
Guangxi Med Univ, Aesthet & Plast Ctr, Nanning, Peoples R ChinaMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Huang, Ying-Ying
;
Hamblin, Michael R.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
Harvard Univ, Sch Med, Dept Dermatol, Boston, MA USA
Harvard Mit Div Hlth Sci & Technol, Cambridge, MA USAMassachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA