Carbon Quantum Dots Modified Polyurethane Nanocomposite as Effective Photocatalytic and Antibacterial Agents

被引:117
作者
Kovacova, Maria [1 ]
Markovic, Zoran M. [1 ,2 ]
Humpolicek, Petr [3 ]
Micusik, Matej [1 ]
Svajdlenkova, Helena [1 ]
Kleinova, Angela [1 ]
Danko, Martin [1 ]
Kubat, Pavel [4 ]
Vajdak, Jan [3 ]
Capakova, Zdenka [3 ]
Lehocky, Marian [3 ]
Munster, Lukas [3 ]
Markovic, Biljana M. Todorovic [2 ]
Spitalsky, Zdeno [1 ]
机构
[1] Slovak Acad Sci, Polymer Inst, Dubrayska Cesta 9, Bratislava 84541, Slovakia
[2] Univ Belgrade, Vinca Inst Nucl Sci, Mike Alasa 12-14, Belgrade 11001, Serbia
[3] Tomas Bata Univ, Ctr Polymer Syst, Zlin 5678, Czech Republic
[4] Acad Sci Czech Republ, J Heyrovsky Inst Phys Chem, Dolejskova 3, CR-18223 Prague 8, Czech Republic
关键词
hydrophobic carbon quantum dots; polyurethane; reactive oxygen species production; photocatalytic activity; antibacterial activity; visible light sterilization; PHOTODYNAMIC THERAPY; METHYLENE-BLUE; SINGLET OXYGEN; LIGHT; NANOPARTICLES; SURFACES; PHOTOLUMINESCENCE; BEHAVIOR; VIOLET;
D O I
10.1021/acsbiomaterials.8b00582
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Development of new types of antibacterial coatings or nanocomposites is of great importance due to widespread multidrug-resistant infections including bacterial infections. Herein, we investigated biocompatibility as well as structural, photocatalytic, and antibacterial properties of photoactive hydrophobic carbon quantum dots/polyurethane nanocomposite. The swell-encapsulation-shrink method was applied for production of these nanocomposites. Hydrophobic carbon quantum dots/polyurethane nanocomposites were found to be highly effective generator of singlet oxygen upon irradiation by low-power blue light. Analysis of conducted antibacterial tests on Staphyloccocus aureus and Escherichia coli showed 5-log bactericidal effect of these nanocomposites within 60 min of irradiation. Very powerful degradation of dye (rose bengal) was observed within 180 min of blue light irradiation of the nanocomposites. Biocompatibility studies revealed that nanocomposites were not cytotoxic against mouse embryonic fibroblast cell line, whereas they showed moderate cytotoxicity toward adenocarcinomic human epithelial cell line. Minor hemolytic effect of these nanocomposites toward red blood cells was revealed.
引用
收藏
页码:3983 / 3993
页数:21
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