Prognostic value of 18 FDG-PET at diagnosis and follow-up in giant cell arteritis: An observational restrospective study

被引:10
作者
Billet, Anne-Claire [1 ]
Thibault, Thomas [2 ]
Liozon, Eric [3 ]
De Boysson, Hubert [2 ,4 ]
Perard, Laurent [5 ]
Espitia, Olivier [6 ]
Daumas, Aurelie [7 ]
Pinho, Quentin Gomes De [8 ]
Durel, Cecile-Audrey [5 ]
Hot, Arnaud [9 ]
Bienvenuj, Boris [10 ]
Humbertk, Sebastien
Bachmeyerl, Claude
Sene, Thomas
Mainbourgm, Sabine
Devilliers, Herve [2 ]
Bailloud, Bastien Durand
Greigert, Helene [1 ]
Cochet, Alexandre
Bonnotte, Bernard [1 ]
Alberini, Jean-Louis
Samson, Maxime [1 ]
机构
[1] Dijon Bourgogne Univ Hosp, Referral Ctr Rare Syst Autoimmune & Autoinflammato, Dept Internal Med & Clin Immunol, Dijon, France
[2] Dijon Bourgogne Univ Hosp, Dept Internal Med & Syst Dis, Dijon, France
[3] Univ Hosp, Dept Internal Med, Limoges, France
[4] Univ Hosp, Dept Internal Med, Caen, France
[5] St Luc St Joseph Hosp, Dept Internal Med, Lyon, France
[6] Nantes Univ, Inst Thorax, Team Vasc & Pulm Dis 3, INSERM UMR1087 CNRS UMR 6291, F-44000 Nantes, France
[7] Aix Marseille Univ, Timone Hosp, APHM, Dept Internal Med, Marseille, France
[8] Aix Marseille Univ, Nord Hosp, APHM, Dept Digest Surg, Marseille, France
[9] Hosp Civils Lyon, Edouard Herriot Hosp, Dept Internal Med, Lyon, France
[10] St Joseph Hosp, Dept Internal Med, Marseille, France
关键词
PET/CT; Giant cell arteritis; Large vessel vasculitis; Relapse; EMISSION-TOMOGRAPHY; AMERICAN-COLLEGE; MANAGEMENT;
D O I
10.1016/j.ejim.2024.03.037
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: To evaluate the ability of 18 FDG PET/CT, at diagnosis of giant cell arteritis (GCA) and during followup, to predict occurrence of relapse in large-vessel GCA (LV-GCA). Methods: We conducted a retrospective study using the French Study Group for Large-Vessel Vasculitis (GEFA) network. Data from patients with LV-GCA diagnosed by PET/CT and who had PET/CT in the following year were collected. For each PET/CT, PET vascular activity score (PETVAS) and total vascular score (TVS) were assessed, and their ability to predict the occurrence of subsequent relapse was assessed. Results: A total of 65 LV-GCA patients were included, of whom 55 had undergone a follow-up PET/CT 3 to 12 months after the diagnosis of GCA. Patients for whom the second PET/CT (PET2) was performed during active GCA were excluded. PETVAS and TVS decreased between PET1 and PET2 in all patients (p p < 0.001). ). There was no correlation between vascular activity scores in PET2 and time to prednisone taper. For relapse prediction, at PET1, the AUC of the TVS and PETVAS were respectively 51.9 and 41.9 at 6 months, 55.3 and 49.7 at 1 year, 55 and 55.7 at 2 years. For PET2, the AUC were respectively 46.1 and 46.7 at 6 months, 52.1 and 48.9 at 1 year, 58.4 and 52.3 at 2 years. Conclusion: PET vascular activity scores at diagnosis and at follow-up PET/CT performed outside a period of GCA activity do not display high performance to predict the occurrence of subsequent relapse in LV-GCA patients.
引用
收藏
页码:69 / 76
页数:8
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