Amino acid metabolic reprogramming in the tumor microenvironment and its implication for cancer therapy

被引：1

作者：

Zhang, Jiarong ^{[1
,2
,3
,4
]}

Chen, Mingjian ^{[1
,4
]}

Yang, Yuxin ^{[1
,4
]}

Liu, Ziqi ^{[1
,4
]}

Guo, Wanni ^{[1
,4
]}

Xiang, Pingjuan ^{[1
,4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
]}

Wang, Dan ^{[1
,2
,3
,4
]}

Xiong, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Cent South Univ, NHC Key Lab Carcinogenesis, Changsha, Peoples R China

[2] Cent South Univ, Hunan Canc Hosp, Hunan Key Lab Canc Metab, Changsha, Peoples R China

[3] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Peoples R China

[4] Cent South Univ, Canc Res Inst, Canc Invas Chinese Minist Educ, Changsha, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2024年 / 239卷 / 11期

关键词：

amino acid metabolism; immune evasion; metabolic reprogramming; tumor microenvironment; tumor resistance; ARYL-HYDROCARBON RECEPTOR; TARGETING GLUTAMINE-METABOLISM; INDOLEAMINE 2,3-DIOXYGENASE; DENDRITIC CELLS; NITRIC-OXIDE; T-CELLS; TRYPTOPHAN-METABOLISM; COLORECTAL-CANCER; PROGNOSTIC VALUE; IDO EXPRESSION;

D O I：

10.1002/jcp.31349

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Amino acids are essential building blocks for proteins, crucial energy sources for cell survival, and key signaling molecules supporting the resistant growth of tumor cells. In tumor cells, amino acid metabolic reprogramming is characterized by the enhanced uptake of amino acids as well as their aberrant synthesis, breakdown, and transport, leading to immune evasion and malignant progression of tumor cells. This article reviews the altered amino acid metabolism in tumor cells and its impact on tumor microenvironment, and also provides an overview of the current clinical applications of amino acid metabolism. Innovative drugs targeting amino acid metabolism hold great promise for precision and personalized cancer therapy. Amino acid metabolic reprogramming in the tumor microenvironment. image

引用

页数：18

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