Sequencing the origins of life

被引：6

作者：

Jia, Tony Z. ^{[1
,2
]}

Nishikawa, Shota ^{[1
,3
]}

Fujishima, Kosuke ^{[1
,4
]}

机构：

[1] Tokyo Inst Technol, Earth Life Sci Inst, 2-12-1-IE-1 Ookayama,Meguro ku, Tokyo 1528550, Japan

[2] Blue Marble Space Inst Sci, 600 1st Ave,Floor 1, Seattle, WA 98104 USA

[3] Tokyo Inst Technol, Sch Life Sci & Technol, Yokohama, Kanagawa 2268501, Japan

[4] Keio Univ, Grad Sch Media & Governance, 5322 Endo, Fujisawa, Kanagawa 2520882, Japan

来源：

BBA ADVANCES | 2022年 / 2卷

基金：

日本学术振兴会;

关键词：

Origin of Life; Chemical Evolution; Astrobiology; Biopolymers; Next-Generation Sequencing; Display methods; TEMPLATE-DIRECTED SYNTHESIS; IN-VITRO SELECTION; RNA-WORLD; PREBIOTIC CHEMISTRY; GENETIC SYSTEM; DNA; EVOLUTION; ACID; RIBOZYMES; GENERATION;

D O I：

10.1016/j.bbadva.2022.100049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One goal of origins of life research is to understand how primitive informational and catalytic biopolymers emerged and evolved. Recently, a number of sequencing techniques have been applied to analysis of replicating and evolving primitive biopolymer systems, providing a sequence -specific and high -resolution view of primitive chemical processes. Here, we review application of sequencing techniques to analysis of synthetic and primitive nucleic acids and polypeptides. This includes next -generation sequencing of primitive polymerization and evolution processes, followed by discussion of other novel biochemical techniques that could contribute to sequence analysis of primitive biopolymer driven chemical systems. Further application of sequencing to origins of life research, perhaps as a life detection technology, could provide insight into the origin and evolution of informational and catalytic biopolymers on early Earth or elsewhere.

引用

页数：8