Efficacy of daprodustat for patients on dialysis with anemia: systematic review and network meta-analysis

被引：0

作者：

Fadlalmola, Hammad Ali ^{[1
]}

Al-Sayaghi, Khaled Mohammed ^{[2
,3
]}

Al-Hebshi, Abdulqader Abdlah ^{[4
]}

Alhujaily, Muhanad ^{[5
]}

Alyamani, Arwa Omar ^{[6
,7
]}

Alem, Alaa Abdulrhman ^{[8
]}

Syrafi, Mona Hamza ^{[9
]}

Alem, Sarah ^{[10
]}

Farhat, Afrah Hassan ^{[11
]}

Mohamed, Fathi Abdelrazig ^{[12
]}

Abdalrahman, Hager Hassan ^{[13
]}

Abdelmalik, Mohammed Abdelkrim ^{[14
,15
]}

Abdalrhman, Neimat Mahmoud ^{[16
]}

Eltayeb, Alamin Mustafa ^{[17
]}

机构：

[1] Taibah Univ, Coll Nursing, Dept Community Hlth Nursing, Al Madinah Al Munawarah, Saudi Arabia

[2] Taibah Univ, Coll Nursing, Dept Med Surg Nursing, Al Madinah Al Munawarah, Saudi Arabia

[3] Sanaa Univ, Fac Med & Hlth Sci, Nursing Div, Sanaa, Yemen

[4] Prince Mohammed Bin AbdulAziz Hosp, Dept Pediat, Pediat Hematol Oncol Serv, Minist Natl Guard Hlth Affairs, Medina, Saudi Arabia

[5] Univ Bisha, Coll Appl Med Sci, Dept Clin Lab Sci, Bisha, Saudi Arabia

[6] King Saud Bin Abdul Azizi Collage Hlth Sci, Dept Pediat, Serv Pediat Hematol Oncol, Riyadh, Saudi Arabia

[7] Minist Natl Guard Hlth Affairs, Princess Noorah Oncol Ctr, Jeddah, Saudi Arabia

[8] Taibah Univ, Coll Med, Dept Med, Nephrol Serv, Medina, Saudi Arabia

[9] King Salman Bin Abdulaziz Med City, Dept Pediat, Serv Pediat Nephrol, Medina, Saudi Arabia

[10] Nahdi Med Co, Medina, Saudi Arabia

[11] King Khalid Univ Hosp, Dept Pediat, Riyadh, Saudi Arabia

[12] Prince Mohammed Bin AbdulAziz Hosp, Dept Pediat, Minist Natl Guard Hlth Affairs, Medina, Saudi Arabia

[13] Univ Hafr Albatin, Coll Appl Med Sci, Hafr Albatin, Saudi Arabia

[14] Shaqra Univ, Coll Appl Med Sci, Dept Nursing, Shaqra, Saudi Arabia

[15] Univ El Imam El Mahdi Kosti, Fac Med & Hlth Sci Nursing, White Nile, Sudan

[16] Al Baha Univ, Med Surg Nursing Dept, Baha, Saudi Arabia

[17] Al Neelain Univ, Fac Med, Khartoum, Sudan

来源：

PAN AFRICAN MEDICAL JOURNAL | 2024年 / 47卷

关键词：

Chronic kidney; daprodustat; network meta -analysis; systematic review; PROLYL HYDROXYLASE INHIBITOR; CHRONIC KIDNEY-DISEASE; EPOETIN-ALPHA; HYPOXIA; ERYTHROPOIETIN; GSK1278863; CKD; HEMODIALYSIS; MECHANISMS; TARGETS;

D O I：

10.11604/pamj.2024.47.114.37278

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Chronic kidney disease (CKD) is commonly complicated by anemia. Treating dialysisdependent patients with anemia, including daprodustat and other inhibitors of prolyl hydroxylase of hypoxia-inducible factor, recombinant human erythropoietin (rhEPO), and iron supplements. We conducted this study to test our postulation; daprodustat is superior to rhEPO and other conventional treatments respecting efficacy and safety parameters. We made systematic search through PubMed, Web of Science, Scopus, and Cochrane. Seven unique trials were eventually included for systematic review; six of them with a sample size of 759 patients entered our network meta -analysis (NMA). Daprodustat 2530 mg was associated with the greatest change in serum hemoglobin (MD=1.86, 95%CI= [1.20; 2.52]), ferritin (MD= -180.84, 95%CI= [-264.47; -97.20]), and total iron binding capacity (TIBC) (MD=11.03, 95%CI= [3.15; 18.92]) from baseline values. Dialysis -dependent patients with anemia had a significant increment in serum Hemoglobin and TIBC and a reduction in serum ferritin, in a dosedependent manner, when administered daprodustat.

引用

页数：16

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