Omission of breast surgery in selected breast cancer patients with excellent response to neoadjuvant systemic therapy

被引：2

作者：

Tasoulis, Marios-Konstantinos ^{[1
,3
]}

Muktar, Samantha

Smith, Ian ^{[2
]}

Roche, Nicola

Macneill, Fiona

机构：

[1] Royal Marsden NHS Fdn Trust, Breast Surg Unit, Fulham Rd, London SW3 6JJ, England

[2] Inst Canc Res, Div Breast Canc Res, London, England

[3] Royal Marsden NHS Fdn Trust, Breast Med Oncol Unit, London, England

来源：

EJSO | 2024年 / 50卷 / 06期

关键词：

Breast cancer; Omission of surgery; Elimination of surgery; Exceptional responders; PATHOLOGICAL COMPLETE RESPONSE; VACUUM ASSISTED BIOPSY; EXCEPTIONAL RESPONDERS; CHEMOTHERAPY;

D O I：

10.1016/j.ejso.2024.108277

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Modern neoadjuvant systemic therapy (NST) can result in high pathologic complete response rates (pCR) in triple negative (TN) and human epidermal growth factor receptor 2 positive (HER2 +) breast cancer. The role of surgery is, therefore, being reconsidered in this rapidly evolving field. This report presents oncological outcomes of seven patients with TN or HER2 + breast cancer, with exceptional response to NST, and a post-NST imageguided vacuum assisted biopsy showing no residual disease (ypT0), who opted not to have breast surgery. The median age was 49 (IQR 36-61) years and the median tumour size at diagnosis was 50 (IQR 16-65) mm. All patients received breast radiotherapy and continued adjuvant systemic therapies as appropriate. At a median follow-up of 67 (IQR 61-77) months, all patients were alive and free of disease. This small case series supports the need for further research in 'exceptional responders' to provide safe, individualized patient -centred care.

引用

页数：4

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