Association of Disrupted Delta Wave Activity During Sleep With Long-Term Cardiovascular Disease and Mortality

被引：13

作者：

Ai, Sizhi ^{[1
,2
]}

Ye, Shuo ^{[2
]}

Li, Guohua ^{[2
]}

Leng, Yue ^{[3
]}

Stone, Katie L. ^{[4
]}

Zhang, Min ^{[5
]}

Wing, Yun-Kwok ^{[6
]}

Zhang, Jihui ^{[1
]}

Liang, Yannis Yan ^{[1
]}

机构：

[1] Guangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou 510370, Guangdong, Peoples R China

[2] Xinxiang Med Univ, Affiliated Hosp 1, Heart Ctr, Dept Cardiol, Weihui, Henan, Peoples R China

[3] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA USA

[4] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[5] Kings Coll London, British Heart Fdn Ctr Res Excellence, Sch Cardiovasc & Metab Med & Sci, London, England

[6] Chinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2024年 / 83卷 / 17期

关键词：

cardiovascular disease; delta wave activity; mortality; spectral entropy; OSTEOPOROTIC FRACTURES; SLOW WAVES; ENTROPY; MEN; ELECTROENCEPHALOGRAPHY; DYNAMICS; DESIGN; BURDEN; HEALTH; RISK;

D O I：

10.1016/j.jacc.2024.02.040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Delta wave activity is a prominent feature of deep sleep, which is signi ficantly associated with sleep quality. OBJECTIVES The authors hypothesized that delta wave activity disruption during sleep could predict long-term cardiovascular disease (CVD) and CVD mortality risk. METHODS The authors used a comprehensive power spectral entropy -based method to assess delta wave activity during sleep based on overnight polysomnograms in 4,058 participants in the SHHS (Sleep Heart Health Study) and 2,193 participants in the MrOS (Osteoporotic Fractures in Men Study) Sleep study. RESULTS During 11.0 +/- 2.8 years of follow-up in SHHS, 729 participants had incident CVD and 192 participants died due to CVD. During 15.5 +/- 4.4 years of follow-up in MrOS, 547 participants had incident CVD, and 391 died due to CVD. In multivariable Cox regression models, lower delta wave entropy during sleep was associated with higher risk of coronary heart disease (SHHS: HR: 1.46; 95% CI: 1.02-2.06; P = 0.03; MrOS: HR: 1.79; 95% CI: 1.17-2.73; P < 0.01), CVD (SHHS: HR: 1.60; 95% CI: 1.21-2.11; P < 0.01; MrOS: HR: 1.43; 95% CI: 1.00-2.05; P = 0.05), and CVD mortality (SHHS: HR: 1.94; 95% CI: 1.18-3.18; P < 0.01; MrOS: HR: 1.66; 95% CI: 1.12-2.47; P = 0.01) after adjusting for covariates. The Shapley Additive Explanations method indicates that low delta wave entropy was more predictive of coronary heart disease, CVD, and CVD mortality risks than conventional sleep parameters. CONCLUSIONS The results suggest that delta wave activity disruption during sleep may be a useful metric to identify those at increased risk for CVD and CVD mortality.

引用

页码：1671 / 1684

页数：14

共 40 条

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