Persistent COVID-19: A Case Report of an Immunocompromised Patient and a Literature Review

被引：0
作者：
Bekkaoui, Sirine [1 ]
Venton, Geoffroy [2 ,3 ,4 ]
Bretelle, Fannie [1 ]
Garrido, Victoria [1 ]
Chabbert, Victor [1 ]
Gayet, Stephane [1 ]
Dalmas, Paul [1 ]
Tichadou, Antoine [2 ,3 ]
Jarrot, Pierre-Andre [5 ,6 ]
Villani, Patrick [1 ,7 ]
Daumas, Aurelie [1 ,6 ]
Arcani, Robin [1 ,6 ]
机构：
[1] CHU La Timone, AP HM, Internal Med & Therapeut Dept, Marseille, France
[2] Univ Hosp Marseille, Hematol & Cellular Therapy Dept, Marseille, France
[3] Aix Marseille Univ, TAGC, INSERM, UMR1090, Marseille, France
[4] Aix Marseille Univ, Pharmacokinet Lab, SMARTc Unit, UMR 911 CRO2, Marseille, France
[5] CHU La Conception, AP HM, Internal Med & Clin Immunol, Marseille, France
[6] Aix Marseille Univ, Ctr Cardiovasc & Nutr Res C2VN, INRA 1260, INSERM,UMR S 1263, Marseille, France
[7] Aix Marseille Univ, CNRS, EFS, ADES, Marseille, France
来源：
ACTA HAEMATOLOGICA | 2024年 / 147卷 / 05期
关键词：
Persistent COVID-19; Severe acute respiratory syndrome coronavirus 2; Immunocompromised patients; B-cell depletion; Convalescent plasma; THERAPY; PLASMA;
D O I：
10.1159/000537793
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Immunocompromised patients can show prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and persistent symptoms, which is called persistent COVID-19. Case Presentation: We report a case of an immunocompromised patient who was treated for mantle cell lymphoma and was suffering from B-cell depletion. The patient developed persistent COVID-19, which was confirmed by real-time polymerase chain reaction (RT-PCR) tests in only sputum and bronchoalveolar fluid which remained positive for at least 112 days. The patient was successfully treated with SARS-CoV-2 convalescent plasma. Conclusion: It could be of interest to investigate the RT-PCR results of SARS-CoV-2 in sputum/bronchoalveolar lavage samples from immunocompromised patients with unexplained pneumonia.
引用
收藏
页码：571 / 575
页数：5
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