The role of the hepatitis B virus genome and its integration in the hepatocellular carcinoma
被引:1
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作者:
Li, Weiyang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Li, Weiyang
[1
,2
]
Wang, Suhao
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Wang, Suhao
[2
]
Jin, Yani
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Jin, Yani
[2
]
Mu, Xiao
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Mu, Xiao
[2
]
Liu, Qingbin
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机构:
Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Liu, Qingbin
[3
,4
]
Cui, Xiaofang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Cui, Xiaofang
[1
,2
]
机构:
[1] Jining Med Univ, Jining, Peoples R China
[2] Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R China
[3] Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
[4] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R China
hepatitis B virus integration;
liver cancer;
genomic instability;
hepatitis B virus infection;
hepatitis B virus;
DOUBLE-STRAND BREAKS;
HBV INTEGRATION;
CIRCULAR DNA;
CLINICAL-FEATURES;
LIVER;
SEQUENCES;
REPAIR;
CELLS;
HOST;
EXPANSION;
D O I:
10.3389/fmicb.2024.1469016
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The integration of Hepatitis B Virus (HBV) is now known to be closely associated with the occurrence of liver cancer and can impact the functionality of liver cells through multiple dimensions. However, despite the detailed understanding of the characteristics of HBV integration and the mechanisms involved, the subsequent effects on cellular function are still poorly understood in current research. This study first systematically discusses the relationship between HBV integration and the occurrence of liver cancer, and then analyzes the status of the viral genome produced by HBV replication, highlighting the close relationship and structure between double-stranded linear (DSL)-HBV DNA and the occurrence of viral integration. The integration of DSL-HBV DNA leads to a certain preference for HBV integration itself. Additionally, exploration of HBV integration hotspots reveals obvious hotspot areas of HBV integration on the human genome. Virus integration in these hotspot areas is often associated with the occurrence and development of liver cancer, and it has been determined that HBV integration can promote the occurrence of cancer by inducing genome instability and other aspects. Furthermore, a comprehensive study of viral integration explored the mechanisms of viral integration and the internal integration mode, discovering that HBV integration may form extrachromosomal DNA (ecDNA), which exists outside the chromosome and can integrate into the chromosome under certain conditions. The prospect of HBV integration as a biomarker was also probed, with the expectation that combining HBV integration research with CRISPR technology will vigorously promote the progress of HBV integration research in the future. In summary, exploring the characteristics and mechanisms in HBV integration holds significant importance for an in-depth comprehension of viral integration.
机构:
Indonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, IndonesiaIndonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, Indonesia
Bianca, Claryssa
Sidhartha, Elizabeth
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Indonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, IndonesiaIndonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, Indonesia
Sidhartha, Elizabeth
Tiribelli, Claudio
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机构:
Fdn Italiana Fegato ONLUS, Ctr Studi Fegato, I-34149 Trieste, ItalyIndonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, Indonesia
Tiribelli, Claudio
El-Khobar, Korri Elvanita
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机构:
Natl Res & Innovat Agcy BRIN, Eijkman Ctr Mol Biol, Jakarta 10340, IndonesiaIndonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, Indonesia
El-Khobar, Korri Elvanita
Sukowati, Caecilia H. C.
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机构:
Fdn Italiana Fegato ONLUS, Ctr Studi Fegato, I-34149 Trieste, Italy
Natl Res & Innovat Agcy BRIN, Eijkman Ctr Mol Biol, Jakarta 10340, Indonesia
Fdn Italiana Fegato ONLUS, Ctr Studi Fegato, AREA Sci Pk,campus Basovizza,SS14 km 163-5, I-34149 Trieste, ItalyIndonesia Int Inst Life Sci, Dept Biomed, Jakarta 13210, Indonesia
机构:
Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Second Mil Med Univ, Changhai Hosp, Dept Lab Med, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Yan, Hongli
Yang, Yuan
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机构:
Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Yang, Yuan
Zhang, Ling
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机构:
Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Zhang, Ling
Tang, Guannan
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Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Tang, Guannan
Wang, YuZhao
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Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Wang, YuZhao
Xue, Geng
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机构:
Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Xue, Geng
Zhou, Weiping
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机构:
Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 3, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
Zhou, Weiping
Sun, Shuhan
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机构:
Second Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R ChinaSecond Mil Med Univ, Dept Med Genet, Shanghai 200433, Peoples R China
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Zhu, Qianqian
Li, Fang
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Li, Fang
Sang, Jiao
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Sang, Jiao
Deng, Huan
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Deng, Huan
Han, Qunying
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Han, Qunying
Lv, Yi
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机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Inst Adv Surg Technol & Engn, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Lv, Yi
Li, Chunyan
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h-index: 0
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Li, Chunyan
Liu, Zhengwen
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h-index: 0
机构:
Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
Xi An Jiao Tong Univ, Inst Adv Surg Technol & Engn, Xian 710061, Shaanxi, Peoples R ChinaXi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China
机构:
Thomas Jefferson Univ Hosp, Dept Med, Philadelphia, PA 19107 USA
Thomas Jefferson Univ Hosp, Div Gastroenterol & Hepatol, Philadelphia, PA 19107 USAThomas Jefferson Univ Hosp, Dept Med, Philadelphia, PA 19107 USA
Halegoua-DeMarzio, Dina
Hann, Hie-Won
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机构:
Thomas Jefferson Univ Hosp, Dept Med, Philadelphia, PA 19107 USA
Thomas Jefferson Univ Hosp, Div Gastroenterol & Hepatol, Philadelphia, PA 19107 USAThomas Jefferson Univ Hosp, Dept Med, Philadelphia, PA 19107 USA
机构:
Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis BR, Tehran, IranUniv Tehran Med Sci, Fac Publ Hlth, Dept Virol, Tehran, Iran
Goodarzi, Zahra
Jazayeri, Seyed Mohamad
论文数: 0引用数: 0
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机构:
Univ Tehran Med Sci, Fac Publ Hlth, Dept Virol, Tehran, IranUniv Tehran Med Sci, Fac Publ Hlth, Dept Virol, Tehran, Iran