The role of the hepatitis B virus genome and its integration in the hepatocellular carcinoma
被引:1
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作者:
Li, Weiyang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Li, Weiyang
[1
,2
]
Wang, Suhao
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Wang, Suhao
[2
]
Jin, Yani
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Jin, Yani
[2
]
Mu, Xiao
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机构:
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Mu, Xiao
[2
]
Liu, Qingbin
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机构:
Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Liu, Qingbin
[3
,4
]
Cui, Xiaofang
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机构:
Jining Med Univ, Jining, Peoples R China
Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R ChinaJining Med Univ, Jining, Peoples R China
Cui, Xiaofang
[1
,2
]
机构:
[1] Jining Med Univ, Jining, Peoples R China
[2] Jining Med Univ, Sch Biol Sci, Rizhao, Peoples R China
[3] Shandong First Med Univ, Jining Peoples Hosp 1, Jining, Peoples R China
[4] Shandong First Med Univ, Jining Peoples Hosp 1, Clin Med Lab Ctr, Jining, Peoples R China
hepatitis B virus integration;
liver cancer;
genomic instability;
hepatitis B virus infection;
hepatitis B virus;
DOUBLE-STRAND BREAKS;
HBV INTEGRATION;
CIRCULAR DNA;
CLINICAL-FEATURES;
LIVER;
SEQUENCES;
REPAIR;
CELLS;
HOST;
EXPANSION;
D O I:
10.3389/fmicb.2024.1469016
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The integration of Hepatitis B Virus (HBV) is now known to be closely associated with the occurrence of liver cancer and can impact the functionality of liver cells through multiple dimensions. However, despite the detailed understanding of the characteristics of HBV integration and the mechanisms involved, the subsequent effects on cellular function are still poorly understood in current research. This study first systematically discusses the relationship between HBV integration and the occurrence of liver cancer, and then analyzes the status of the viral genome produced by HBV replication, highlighting the close relationship and structure between double-stranded linear (DSL)-HBV DNA and the occurrence of viral integration. The integration of DSL-HBV DNA leads to a certain preference for HBV integration itself. Additionally, exploration of HBV integration hotspots reveals obvious hotspot areas of HBV integration on the human genome. Virus integration in these hotspot areas is often associated with the occurrence and development of liver cancer, and it has been determined that HBV integration can promote the occurrence of cancer by inducing genome instability and other aspects. Furthermore, a comprehensive study of viral integration explored the mechanisms of viral integration and the internal integration mode, discovering that HBV integration may form extrachromosomal DNA (ecDNA), which exists outside the chromosome and can integrate into the chromosome under certain conditions. The prospect of HBV integration as a biomarker was also probed, with the expectation that combining HBV integration research with CRISPR technology will vigorously promote the progress of HBV integration research in the future. In summary, exploring the characteristics and mechanisms in HBV integration holds significant importance for an in-depth comprehension of viral integration.
机构:
Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R ChinaPrince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
Chan, HLY
Sung, JJY
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机构:
Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R ChinaPrince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
机构:
Jining Med Univ, Jining 272067, Shandong, Peoples R China
Jining Med Univ, Collaborat Innovat Ctr Birth Defect Res & Transfo, Jining 272067, Shandong, Peoples R ChinaJining Med Univ, Jining 272067, Shandong, Peoples R China
Li, Weiyang
Qi, Yanwei
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机构:
Jining Med Univ, Jining 272067, Shandong, Peoples R ChinaJining Med Univ, Jining 272067, Shandong, Peoples R China
Qi, Yanwei
Xu, Hanshi
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机构:
Sun Yat Sen Univ, Canc Ctr, Dept Nasopharyngeal Carcinoma, Guangzhou, Guangdong, Peoples R ChinaJining Med Univ, Jining 272067, Shandong, Peoples R China
Xu, Hanshi
Wei, Wei
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机构:
Jining Med Univ, Jining 272067, Shandong, Peoples R ChinaJining Med Univ, Jining 272067, Shandong, Peoples R China
Wei, Wei
Cui, Xiaofang
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机构:
Jining Med Univ, Jining 272067, Shandong, Peoples R China
Jining Med Univ, Sch Mental Hlth, Shandong Key Lab Behav Med, Jining 272067, Shandong, Peoples R ChinaJining Med Univ, Jining 272067, Shandong, Peoples R China