Exploring the link: Porto-sinusoidal vascular disorder and inflammatory bowel disease - A comprehensive narrative review

被引：5

作者：

Pugliese, Nicola ^{[1
,2
]}

Giuli, Lucia ^{[3
]}

Mastrorocco, Elisabetta ^{[1
]}

Santopaolo, Francesco ^{[3
]}

Marcozzi, Giacomo ^{[1
]}

Bezzio, Cristina ^{[1
,4
]}

Dal Buono, Arianna ^{[1
,4
]}

Gabbiadini, Roberto ^{[1
,4
]}

Gasbarrini, Antonio ^{[3
,5
]}

Ponziani, Francesca Romana ^{[3
,5
]}

Armuzzi, Alessandro ^{[1
,4
]}

Aghemo, Alessio ^{[1
,2
,6
]}

机构：

[1] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy

[2] IRCCS Humanitas Res Hosp, Dept Gastroenterol, Div Internal Med & Hepatol, Rozzano, MI, Italy

[3] Fdn Policlin Univ Gemelli IRCCS, CEMAD Ctr Malattie Apparat Digerente Med Interna &, Hepatol Unit, I-00168 Rome, Italy

[4] IRCCS Humanitas Res Hosp, IBD Ctr, Dept Gastroenterol, Rozzano, MI, Italy

[5] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslaz, I-00168 Rome, Italy

[6] Univ Hosp, Via A Manzoni 56, I-20089 Rozzano, MI, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2024年 / 56卷 / 06期

关键词：

Inflammatory bowel disease (IBD); Nodular regenerative hyperplasia (NRH); Porto-sinusoidal vascular disorder (PSVD); Portal hypertension (PH); NODULAR REGENERATIVE HYPERPLASIA; THIOPURINE THERAPY; HEPATOPORTAL SCLEROSIS; CROHNS-DISEASE; IBD PATIENTS; LIVER; AZATHIOPRINE; HYPERTENSION; 6-THIOGUANINE; THIOGUANINE;

D O I：

10.1016/j.dld.2023.11.021

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Porto-sinusoidal vascular disorder (PSVD) encompasses a group of vascular disorders characterized by lesions involving the portal venules and sinusoids, independent of the presence of portal hypertension (PH), and for which liver biopsy is essential for diagnosis. PSVD has been shown to be common in patients with immune-mediated diseases, including inflammatory bowel disease (IBD). The association between PSVD and the use of thiopurines and thioguanine in patients with IBD has been well established. In addition, research suggests an association between PSVD and IBD, even in cases where patients haven't been exposed to specific medications, probably related to changes in intestinal permeability. The identification and management of patients with known IBD and PSVD is a challenge for gastroenterologists. This narrative review aims to summarize the currently available data on the association between IBD and PSVD and provide practical suggestions for the management of this group of patients. (c) 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：964 / 970

页数：7

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