Genetic Variations of African Swine Fever Virus: Major Challenges and Prospects

被引：9

作者：

Chen, Shengmei ^{[1
,2
]}

Wang, Tao ^{[2
]}

Luo, Rui ^{[2
]}

Lu, Zhanhao ^{[2
]}

Lan, Jing ^{[2
,3
]}

Sun, Yuan ^{[2
]}

Fu, Qiang ^{[1
]}

Qiu, Hua-Ji ^{[1
,2
,3
]}

机构：

[1] Foshan Univ, Coll Life Sci & Engn, Foshan 528231, Peoples R China

[2] Chinese Acad Agr Sci, State Key Lab Anim Dis Control & Prevent, Natl African Swine Fever Para Reference Lab, Harbin Vet Res Inst,Natl High Containment Facil An, Harbin 150069, Peoples R China

[3] Yangtze Univ, Coll Anim Sci, Jingzhou 434023, Peoples R China

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 06期

基金：

中国国家自然科学基金;

关键词：

African swine fever; African swine fever virus; mutations; recombination; vaccines; POLYMERASE; INFECTION; GENOME;

D O I：

10.3390/v16060913

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

African swine fever (ASF) is a contagious viral disease affecting pigs and wild boars. It typically presents as a hemorrhagic fever but can also manifest in various forms, ranging from acute to asymptomatic. ASF has spread extensively globally, significantly impacting the swine industry. The complex and highly variable character of the ASFV genome makes vaccine development and disease surveillance extremely difficult. The overall trend in ASFV evolution is towards decreased virulence and increased transmissibility. Factors such as gene mutation, viral recombination, and the strain-specificity of virulence-associated genes facilitate viral variations. This review deeply discusses the influence of these factors on viral immune evasion, pathogenicity, and the ensuing complexities encountered in vaccine development, disease detection, and surveillance. The ultimate goal of this review is to thoroughly explore the genetic evolution patterns and variation mechanisms of ASFV, providing a theoretical foundation for advancement in vaccine and diagnostic technologies.

引用

页数：18

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