Development and therapeutic perspectives of CXCR4 antagonists for disease therapy

被引：2

作者：

Yang, Jun ^{[1
,2
,3
,4
,5
]}

Tian, Erkang ^{[6
,7
]}

Chen, Li ^{[1
,2
,3
,4
,5
]}

Liu, Zihang ^{[1
,2
,3
,4
,5
]}

Ren, Yijiu ^{[8
]}

Mao, Wuyu ^{[1
,2
,3
,4
,5
]}

Zhang, Yiwen ^{[1
,2
,3
,4
,5
]}

Zhang, Jifa ^{[1
,2
,3
,4
,5
]}

机构：

[1] Sichuan Univ, Lab Neurosyst & Multimorbid, Dept Neurol, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, Inst Resp Hlth, Chengdu 610041, Sichuan, Peoples R China

[5] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[7] Sichuan Univ, West China Hosp Stomatol, Dept Orthodont, Chengdu 610041, Peoples R China

[8] Tongji Univ, Shanghai Pulm Hosp, Dept Thorac Surg, Sch Med, Shanghai 200433, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 275卷

基金：

中国国家自然科学基金;

关键词：

CXCR4; Antagonists; HIV; Cancer; Drug design; Structure -activity relationship; CHEMOKINE RECEPTOR CXCR4; HUMAN-IMMUNODEFICIENCY-VIRUS; STEM-CELL MOBILIZERS; SMALL-MOLECULE; BETA-ARRESTIN; WHIM-SYNDROME; LUNG-CANCER; HIV ENTRY; DISCOVERY; IDENTIFICATION;

D O I：

10.1016/j.ejmech.2024.116594

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is involved in diseases (e.g., HIV -1 infection), cancer proliferation and metastasis, inflammation signaling pathways, and leukemia, making it a promising drug target. Clinical trials on CXCR4 antagonists mainly focused on peptides and antibodies, with a few small molecule compounds, such as AMD11070 ( 2 ) and MSX-122 ( 3 ), showing promise in cancer treatment. This perspective discusses the structure -activity relationship (SAR) of CXCR4 and its role in diseases, mainly focusing on the SAR of CXCR4 antagonists. It also explores the standard structural features and target interactions of CXCR4 binding in different disease categories. Furthermore, it investigates various modification strategies to propose potential improvements in the effectiveness of CXCR4 drugs.

引用

页数：18

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