Interleukin-6 promotes visceral adipose tissue accumulation during aging via inhibiting fat lipolysis

被引：1

作者：

Zhang, Xiaofang ^{[1
]}

Wang, Qingxuan ^{[1
]}

Wang, Yaru ^{[1
]}

Ma, Chen ^{[1
]}

Zhao, Qing ^{[1
]}

Yin, Hongyan ^{[1
]}

Li, Long ^{[1
,2
]}

Wang, Dongmei ^{[1
,3
]}

Huang, Yinxiang ^{[1
]}

Zhao, Yan ^{[1
]}

Shi, Xiulin ^{[1
]}

Li, Xuejun ^{[1
,4
]}

Huang, Caoxin ^{[1
,4
]}

机构：

[1] Xiamen Univ, Affiliated Hosp 1, Xiamen Diabet Inst, Sch Med,Fujian Key Lab Translat Res Diabet,Dept En, Xiamen 361003, Peoples R China

[2] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China

[3] Xiamen Med Coll, Dept Publ Hlth & Med Technol, Xiamen 361023, Peoples R China

[4] Xiamen Univ, Affiliated Hosp 1, Xiamen Diabet Inst, Sch Med,Fujian Province Key Lab Translat Res Diabe, 55 Zhenhai Rd, Xiamen 361003, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 132卷

基金：

中国国家自然科学基金;

关键词：

Aging; Visceral adipose; IL-6; Lipolysis; Obesity; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; PROINFLAMMATORY CYTOKINES; RHEUMATOID-ARTHRITIS; SIGNALING PATHWAY; DOUBLE-BLIND; BODY-WEIGHT; IN-VITRO; IL-6;

D O I：

10.1016/j.intimp.2024.111906

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Age-related visceral obesity could contribute to the development of cardiometabolic complications. The pathogenesis of visceral fat mass accumulation during the aging process remains complex and largely unknown. Interleukin-6 (IL-6) has emerged as one of the prominent inflammaging markers which are elevated in circulation during aging. However, the precise role of IL-6 in regulating age-related visceral adipose tissue accumulation remains uncertain. Results: A cross-sectional study including 77 older adults (>= 65 years of age) was initially conducted. There was a significant positive association between serum IL-6 levels and visceral fat mass. We subsequently validated a modest but significant elevation in serum IL-6 levels in aged mice. Furthermore, we demonstrated that compared to wildtype control, IL-6 deficiency (IL-6 KO) significantly attenuated the accumulation of visceral adipose tissue during aging. Further metabolic characterization suggested that IL-6 deficiency resulted in improved lipid metabolism parameters and energy expenditure in aged mice. Moreover, histological examinations of adipose depots revealed that the absence of IL-6 ameliorated adipocyte hypertrophy in visceral adipose tissue of aged mice. Mechanically, the ablation of IL-6 could promote the PKA-mediated lipolysis and consequently mitigate lipid accumulation in adipose tissue in aged mice. Conclusion: Our findings identify a detrimental role of IL-6 during the aging process by promoting visceral adipose tissue accumulation through inhibition of lipolysis. Therefore, strategies aimed at preventing or reducing IL-6 levels may potentially ameliorate age-related obesity and improve metabolism during aging.

引用

页数：12

共 107 条

[81] Adipocyte-specific deficiency of Janus kinase (JAK) 2 in mice impairs lipolysis and increases body weight, and leads to insulin resistance with ageing [J].