Sublime Microglia: Expanding Roles for the Guardians of the CNS

被引：432
作者：
Salter, Michael W. [1 ,2 ,3 ]
Beggs, Simon [1 ,3 ]
机构：
[1] Univ Toronto, Ctr Study Pain, Neurosci & Mental Hlth Program, Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Ctr Study Pain, Dept Physiol, Fac Med, Toronto, ON M5G 1X8, Canada
[3] Univ Toronto, Ctr Study Pain, Dept Physiol, Fac Dent, Toronto, ON M5G 1X8, Canada
来源：
CELL | 2014年 / 158卷 / 01期
基金：
加拿大健康研究院;
关键词：
TISSUE-RESIDENT MACROPHAGES; ONSET ALZHEIMERS-DISEASE; NEUROPATHIC PAIN; NEUROTROPHIC FACTOR; HIPPOCAMPAL NEUROGENESIS; IN-VIVO; TRANSCRIPTION FACTOR; ANION GRADIENT; NEURONAL DEATH; KNOCKOUT MICE;
D O I：
10.1016/j.cell.2014.06.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the structure of the CNS, refine neuronal circuitry and network connectivity, and contribute to plasticity. These physiological functions of microglia in the normal CNS begin during development and persist into maturity. Here, we develop a conceptual framework for functions of microglia beyond neuroinflammation and discuss the rich repertoire of signaling and communication motifs in microglia that are critical both in pathology and for the normal physiology of the CNS.
引用
收藏
页码：15 / 24
页数：10
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