T-Cell/B-Cell Interactions in Atherosclerosis

被引：3

作者：

Jones, Peter William ^{[1
]}

Mallat, Ziad ^{[1
,2
]}

Nus, Meritxell ^{[1
]}

机构：

[1] Univ Cambridge, Heart & Lung Res Inst, Dept Med, Cardiovasc Div, Cambridge Biomedical Campus,Papworth Rd, Cambridge CB2 0BB, England

[2] INSERM, Paris Cardiovasc Res Ctr, U970, Paris, France

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2024年 / 44卷 / 07期

关键词：

adaptive immunity; atherosclerosis; B lymphocyte; humans; T lymphocytes; OXIDATION-SPECIFIC EPITOPES; REDUCES ATHEROSCLEROSIS; DEFICIENT MICE; LDL; KNOCKOUT; PROTECTS; IGM; INTERLEUKIN-12; ATHEROGENESIS; INFLAMMATION;

D O I：

10.1161/ATVBAHA.124.319845

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is a complex inflammatory disease in which the adaptive immune response plays an important role. While the overall impact of T and B cells in atherosclerosis is relatively well established, we are only beginning to understand how bidirectional T-cell/B-cell interactions can exert prominent atheroprotective and proatherogenic functions. In this review, we will focus on these T-cell/B-cell interactions and how we could use them to therapeutically target the adaptive immune response in atherosclerosis.

引用

页码：1502 / 1511

页数：10

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