Circulating IgG Fragments for Gastric Cancer and Esophageal Cancer

被引:0
作者
Goufman, Eugene I. [1 ]
Tikhonova, Nataliia B. [1 ]
Aleksankin, Andrey P. [1 ]
Gershkovich, Karina B. [2 ]
Stepanov, Alexander A. [1 ]
Stepanova, Irina I. [1 ]
Mikhaleva, Liudmila M. [1 ]
Nizyaeva, Natalia V. [1 ]
Kovaleva, Olga V. [3 ]
Alferov, Alexander A. [3 ]
Kuzmin, Yury B. [3 ]
Kushlinskii, Nikolay E. [3 ]
机构
[1] Petrovsky Natl Res Ctr Surg, Avtsyn Res Inst Human Morphol, Fed State Budgetary Sci Inst, Moscow 117418, Russia
[2] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Moscow 119334, Russia
[3] NN Blokhin Natl Med Res Ctr Oncol, Fed State Budgetary Inst, Moscow 115478, Russia
关键词
gastric cancer; esophageal cancer; tumor proteolysis activity; IgG fragments with C-terminal lysine; PLASMINOGEN ACTIVATION; EPIDEMIOLOGY; CLEAVAGE;
D O I
10.3390/diagnostics14131396
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Blood serum of patients with gastric (n = 68) and esophageal (n = 43) cancer was assessed for proteolytic fragments of IgG. Serum samples of 20 healthy donors were used as a control. We analyzed indicators of hemostasis (prothrombin time, fibrinogen, plasminogen activity, a2-antiplasmin activity, protein C activity) in blood plasma and the level of total IgG in the blood serum. The median IgG-LysK of healthy donors was lower than in esophageal cancer and in patients with gastric cancer. ROC-analysis showed high sensitivity (91%) and specificity (85%) in the group with esophageal cancer but 68% and 85%, respectively, in patients with gastric cancer. Analysis of false negatives IgG-LysK in cancer patients showed that most patients had an advanced stage of cancer accompanied by metastases. Total IgG in the plasma of patients with false-negative IgG-LysK values was 30% lower than in samples with positive values, while the level of a2-antiplasmin was increased and the prothrombin time was shorter. These changes in blood homeostasis may be the reason for an increase in the proportion of false-negative values of the IgG-LysK coefficient. Circulatory IgG-LysK levels increase in the early stages of such cancers as gastric and esophageal cancers. Thus, when used in a panel with other more specific markers for these pathologies, this indicator can significantly increase the early detection of cancer.
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页数:13
相关论文
共 42 条
[1]   Effect of Specific Cleavage of Immunoglobulin G by Plasmin on the Binding and Activation of Plasminogen [J].
Aisina, R. B. ;
Mukhametova, L. I. ;
Gershkovich, K. B. ;
Yakovlev, V. N. ;
Goufman, E. I. ;
Tikhonova, N. B. .
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2018, 44 (02) :210-216
[2]   The plasminogen activation system in tumor growth, invasion, and metastasis [J].
Andreasen, PA ;
Egelund, R ;
Petersen, HH .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (01) :25-40
[3]   Global Burden of 5 Major Types of Gastrointestinal Cancer [J].
Arnold, Melina ;
Abnet, Christian C. ;
Neale, Rachel E. ;
Vignat, Jerome ;
Giovannucci, Edward L. ;
McGlynn, Katherine A. ;
Bray, Freddie .
GASTROENTEROLOGY, 2020, 159 (01) :335-+
[4]  
Artemyeva K.A., 2022, Clin. Exp. Morphol, V11, P22, DOI [10.31088/CEM2022.11.2.22-31, DOI 10.31088/CEM2022.11.2.22-31]
[5]   C-Terminal Lysine Processing of IgG in Human Suction Blister Fluid: Implications for Subcutaneous Administration [J].
Ayalew, Luladey ;
Chan, Phyllis ;
Hu, Zhilan ;
Shen, Amy ;
Duenas, Eileen ;
Kirschbrown, Whitney ;
Schick III, Arthur J. ;
Chen, Yan ;
Kim, Michael T. .
MOLECULAR PHARMACEUTICS, 2022, 19 (11) :4043-4054
[6]  
Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
[7]   Cleavage of IgGs by proteases associated with invasive diseases An evasion tactic against host immunity? [J].
Brezski, Randall J. ;
Jordan, Robert E. .
MABS, 2010, 2 (03) :212-220
[8]  
Cainap Calin, 2015, Clujul Med, V88, P111, DOI 10.15386/cjmed-409
[9]   CHARACTERIZATION OF A PLASMIN-DIGEST FRAGMENT OF RABBIT IMMUNOGLOBULIN GAMMA THAT BINDS ANTIGEN AND COMPLEMENT [J].
COLOMB, M ;
PORTER, RR .
BIOCHEMICAL JOURNAL, 1975, 145 (02) :177-183
[10]   Plasminogen activation and cancer [J].
Dano, K ;
Behrendt, N ;
Hoyer-Hansen, G ;
Johnsen, M ;
Lund, LR ;
Ploug, M ;
Romer, J .
THROMBOSIS AND HAEMOSTASIS, 2005, 93 (04) :676-681