A Recurring Theme: A Rare Case of Pembrolizumab-induced Acute Interstitial Nephritis

被引：0

作者：

London, Jonathan ^{[1
]}

Bulancea, Sabrina ^{[1
]}

Shirazi, Inaas ^{[1
]}

Oriuwa, Victoria ^{[1
]}

Bolotova, Olena ^{[2
]}

Tharayil, Zubin ^{[1
]}

机构：

[1] Long Isl Community Hosp, Dept Internal Med, Patchogue, NY 11772 USA

[2] Long Isl Community Hosp, Dept Nephrol, Patchogue, NY USA

来源：

JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES | 2024年 / 14卷 / 04期

关键词：

Pembrolizumab; Acute interstitial nephritis;

D O I：

10.55729/2000-9666.1362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pembrolizumab is utilized in the treatment of multiple different malignancies, including non -small cell lung cancer, head and neck squamous cell carcinoma, melanoma, renal cell carcinoma, endometrial cancer, and more. Pembrolizumab is an immune checkpoint inhibitor that inhibits the programmed cell death -1 (PD-1) signaling pathway. Despite its bene fi ts in treating multiple cancers, there are many reported adverse effects of Pembrolizumab affecting various organ systems; rarely it can cause acute interstitial nephritis (AIN). We present the case of a 79-year-old male with metastatic retroperitoneal squamous cell carcinoma who was found to have recurrent acute interstitial nephritis after pembrolizumab therapy.

引用

页数：5

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