Intermittent administration of PTH for the treatment of inflammatory bone loss does not enhance entheseal pathological new bone formation

被引：0
作者：
Zhang, Shuai [1 ,2 ]
Hao, Wenjun [1 ,2 ]
Chen, Dongying [3 ]
Chen, Siwen [1 ,2 ]
Li, Zihao [1 ,2 ]
Zhong, Fangling [1 ,2 ]
Wang, Haitao [1 ,2 ]
Wang, Jianru [1 ,2 ]
Zheng, Zhaomin [1 ,2 ]
Zhan, Zhongping [3 ]
Dai, Guo [1 ,2 ]
Liu, Hui [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Spine Surg, Guangzhou 510080, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Orthopaed & Traumatol, Guangzhou 510080, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol & Immunol, Guangzhou 510080, Guangdong, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2024年 / 711卷
关键词：
Parathyroid hormone; Ankylosing spondylitis; Osteoporosis; Pathological new bone formation; Endochondral ossification; MESENCHYMAL STEM-CELLS; PARATHYROID-HORMONE; INDUCED OSTEOPOROSIS; ANABOLIC ACTIVITY; MINERAL DENSITY; ANIMAL-MODELS; MOUSE MODEL; GROWTH; ARTHRITIS; SPONDYLOARTHRITIS;
D O I：
10.1016/j.bbrc.2024.149888
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Objective: To investigate the effect of intermittent parathyroid hormone (iPTH) administration on pathological new bone formation during treatment of ankylosing spondylitis-related osteoporosis. Methods: Animal models with pathological bone formation caused by hypothetical AS pathogenesis received treatment with iPTH. We determined the effects of iPTH on bone loss and the formation of pathological new bone with micro-computed tomography (micro-CT) and histological examination. In addition, the tamoxifen-inducible conditional knockout mice (CAGGCre-ERTM; PTH flox/flox, PTH-/-) was established to delete PTH and investigate the effect of endogenous PTH on pathological new bone formation. Results: iPTH treatment significantly improved trabecular bone mass in the modified collagen-induced arthritis (m-CIA) model and unbalanced mechanical loading models. Meanwhile, iPTH treatment did not enhance pathological new bone formation in all types of animal models. Endogenous PTH deficiency had no effects on pathological new bone formation in unbalanced mechanical loading models. Conclusion: Experimental animal models of AS treated with iPTH show improvement in trabecular bone density, but not entheseal pathological bone formation,indicating it may be a potential treatment for inflammatory bone loss does in AS.
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页数：14
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共 76 条
[1]   Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA [J].
Bagi, Cedo M. ;
Berryman, Edwin ;
Zakur, David E. ;
Wilkie, Dean ;
Andresen, Catharine J. .
ARTHRITIS RESEARCH & THERAPY, 2015, 17
[2]   A longitudinal study on an autoimmune murine model of ankylosing spondylitis [J].
Bárdos, T ;
Szabó, Z ;
Czipri, M ;
Vermes, C ;
Tunyogi-Csapó, M ;
Urban, RM ;
Mikecz, K ;
Glant, TT .
ANNALS OF THE RHEUMATIC DISEASES, 2005, 64 (07) :981-987
[3]   Where tendons and ligaments meet bone: attachment sites ('entheses') in relation to exercise and/or mechanical load [J].
Benjamin, M ;
Toumi, H ;
Ralphs, JR ;
Bydder, G ;
Best, TM ;
Milz, S .
JOURNAL OF ANATOMY, 2006, 208 (04) :471-490
[4]   Evidence for a distinctive pattern of bone formation in enthesophytes [J].
Benjamin, M. ;
Toumi, H. ;
Suzuki, D. ;
Hayashi, K. ;
McGonagle, D. .
ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (06) :1003-1010
[5]   Bone development [J].
Berendsen, Agnes D. ;
Olsen, Bjorn R. .
BONE, 2015, 80 :14-18
[6]   Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone [J].
Bikle, DD ;
Sakata, T ;
Leary, C ;
Elalieh, H ;
Ginzinger, D ;
Rosen, CJ ;
Beamer, W ;
Majumdar, S ;
Halloran, BP .
JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (09) :1570-1578
[7]   Collagen-induced arthritis [J].
Brand, David D. ;
Latham, Kary A. ;
Rosloniec, Edward F. .
NATURE PROTOCOLS, 2007, 2 (05) :1269-1275
[8]   Animal Models of Spondyloarthritis: Do They Faithfully Mirror Human Disease? [J].
Breban, Maxime ;
Araujo, Luiza M. ;
Chiocchia, Gilles .
ARTHRITIS & RHEUMATOLOGY, 2014, 66 (07) :1689-1692
[9]   Inflammatory Rheumatic Disorders and Bone [J].
Bultink, Irene E. M. ;
Vis, Marijn ;
van der Horst-Bruinsma, Irene E. ;
Lems, Willem F. .
CURRENT RHEUMATOLOGY REPORTS, 2012, 14 (03) :224-230
[10]   Mechanisms of anabolic therapies for osteoporosis [J].
Canalis, Ernesto ;
Giustina, Andrea ;
Bilezikian, John P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (09) :905-916
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