Tailoring neo/adjuvant systemic therapy in breast cancer: "The advent of a personalized approach"-The Breast-Gynecological and Immuno-Oncology International Cancer Conference (BGICC) consensus and recommendations

被引：1

作者：

Elghazaly, Hesham ^{[1
]}

Azim, Hamdy A. ^{[2
]}

Rugo, Hope S. ^{[3
]}

Cameron, David ^{[4
,5
]}

Swain, Sandra M. ^{[6
]}

Curigliano, Giuseppe ^{[7
]}

Harbeck, Nadia ^{[8
,9
]}

Tripathy, Debu ^{[10
]}

Arun, Banu ^{[10
]}

Aapro, Matti ^{[11
]}

Piccart, Martine ^{[12
,13
]}

Cardoso, Fatima ^{[14
]}

Gligorov, Joseph ^{[15
]}

Elghazawy, Hagar ^{[1
]}

El Saghir, Nagi S. ^{[16
]}

Penault-Llorca, Frederique ^{[17
]}

Perez, Edith A. ^{[18
]}

Poortmans, Philip ^{[19
,20
]}

Abdelaziz, Hany ^{[1
]}

El-Zawahry, Heba M. ^{[2
]}

Kassem, Loay ^{[2
]}

Sabry, Mohamed ^{[1
]}

Viale, Giuseppe ^{[21
]}

Al-Sukhun, Sana ^{[22
]}

Gado, Neven ^{[1
]}

Leung, Jessica W. T. ^{[23
]}

Ezz Elarab, Lobna ^{[1
]}

Cardoso, Maria Joao ^{[24
]}

Abdel Karim, Khaled ^{[1
]}

Foheidi, Meteb ^{[25
]}

Elmaadawy, Merit M. ^{[26
]}

Conte, Pierfranco ^{[27
,28
]}

Selim, Ashraf S. M. ^{[29
]}

Kandil, Alaa ^{[30
]}

Kamal, Rasha M. ^{[29
]}

Paltuev, Ruslan M. ^{[31
]}

Guarneri, Valentina ^{[27
,28
]}

Abulkhair, Omalkhair ^{[32
]}

Zakaria, Omar ^{[33
]}

Golshan, Mehra ^{[34
]}

Orecchia, Roberto ^{[35
]}

Elmahdy, Manal ^{[36
]}

Abdel-Aziz, Ahmed M. ^{[37
]}

Eldin, Nermean Bahie ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Med, Dept Clin Oncol, Cairo, Egypt

[2] Cairo Univ, Kasr Alainy Sch Med, Dept Clin Oncol, Giza, Egypt

[3] Univ Calif San Francisco, Comprehens Canc Ctr, Dept Med, San Francisco, CA USA

[4] Univ Edinburgh, Inst Genet & Canc, Edinburgh Canc Res Ctr, Edinburgh, Scotland

[5] Natl Hlth Serv Lothian, Edinburgh, Scotland

[6] MedStar Hlth, Georgetown Lombardi Comprehens Canc Ctr, Washington, DC USA

[7] Univ Milan, European Inst Oncol, Dept Oncol & Hematooncol, IRCCS, Milan, Italy

[8] Ludwig Maximilian Univ Hosp, Dept Obstet & Gynecol, Munich, Germany

[9] Ludwig Maximilian Univ Hosp, Comprehens Canc Ctr Munich, Breast Ctr, Munich, Germany

[10] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX USA

[11] Clin Genolier, Breast Ctr, Genolier, Switzerland

[12] Inst Jules Bordet, Brussels, Belgium

[13] Univ Libre Bruxelles, Brussels, Belgium

[14] Champalimaud Fdn, Champalimaud Clin Ctr, Breast Unit, Lisbon, Portugal

[15] Sorbonne Univ, Inst Univ Cancerol, Assistance Publ Hop Paris, Med Oncol Dept, Paris, France

[16] Amer Univ Beirut, Med Ctr, Dept Internal Med, Div Hematol Oncol, Beirut, Lebanon

[17] Clermont Auvergne Univ, Ctr Jean Perrin, Natl Inst Hlth & Med Res,Dept Pathol, Unit Mol Imaging & Theranost Strategies 1240, Clermont Ferrand, France

[18] Mayo Clin, Dept Hematol & Oncol, Jacksonville, FL USA

[19] Univ Antwerp, Iridium Network, Antwerp, Belgium

[20] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium

[21] IRCCS, European Inst Oncol, Milan, Italy

[22] Al Hyatt Oncol Practice, Amman, Jordan

[23] Univ Texas MD Anderson Canc Ctr, Dept Breast Imaging, Div Diagnost Imaging, Houston, TX USA

[24] Champalimaud Fdn, Champalimaud Clin Ctr, Breast Unit, Fac Med, Lisbon, Portugal

[25] King Saud Bin Abdulaziz Univ Hlth Sci, Princess Noorah Oncol Ctr, King Abdulaziz Med City, Minist Natl Guard Hlth Affairs Western Reg,Coll Me, Jeddah, Saudi Arabia

[26] Mansoura Univ, Diagnost Radiol Dept, Mansoura, Egypt

[27] Padova Univ, Dept Surg Oncol & Gastroenterol, Padua, Italy

[28] Ist Oncol Veneto IRCCS, Div Oncol, Padua, Italy

[29] Cairo Univ, Diagnost & Intervent Radiol Dept, Giza, Egypt

[30] Alexandria Sch Med, Dept Clin Oncol, Alexandria, Egypt

[31] Russian Assoc Oncol Mammol, Fed State Budgetary Inst, Dept Breast Tumours, Petrov Res Inst Oncol, St Petersburg, Russia

[32] Alhabib Hosp, Med Oncol Dept, Oncol Serv, Riyadh, Saudi Arabia

[33] Cairo Univ, Dept Surg, Cairo, Egypt

[34] Yale Univ, Sch Med, Yale Comprehens Canc Ctr, Dept Surg, New Haven, CT USA

[35] Univ Milan, IRCCS European Inst Oncol, Sci Directorate, Milan, Italy

[36] Ain Shams Univ, Dept Pathol, Cairo, Egypt

[37] Cairo Univ, Fac Med, Dept Pathol, Giza, Egypt

来源：

CANCER | 2024年 / 130卷 / 19期

关键词：

adjuvant therapy; breast cancer; HER2-positive breast cancer; hormone receptor-positive breast cancer; neoadjuvant therapy; triple-negative breast cancer; PATHOLOGICAL COMPLETE RESPONSE; NEOADJUVANT ENDOCRINE THERAPY; ENHANCED SPECTRAL MAMMOGRAPHY; EVENT-FREE SURVIVAL; OPEN-LABEL; STAGE-II; ADJUVANT CHEMOTHERAPY; POSTMENOPAUSAL WOMEN; ANTHRACYCLINE-FREE; LOBULAR CARCINOMA;

D O I：

10.1002/cncr.35389

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The management of early breast cancer (BC) has witnessed an uprise in the use of neoadjuvant therapy and a remarkable reshaping of the systemic therapy postneoadjuvant treatment in the last few years, with the evolution of many controversial clinical situations that require consensus. Methods: During the 14th Breast-Gynecological and Immuno-Oncology International Cancer Conference held in Egypt in 2022, a panel of 44 BC experts from 13 countries voted on statements concerning debatable challenges in the neo/adjuvant treatment setting. The recommendations were subsequently updated based on the most recent data emerging. A modified Delphi approach was used to develop this consensus. A consensus was achieved when >= 75% of voters selected an answer. Results and Conclusions: The consensus recommendations addressed different escalation and de-escalation strategies in the setting of neoadjuvant therapy for early BC. The recommendations recapitulate the available clinical evidence and expert opinion to individualize patient management and optimize therapy outcomes. Consensus was reached in 63% of the statements (52/83), and the rationale behind each statement was clarified.

引用

页码：3251 / 3271

页数：21

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