The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults

被引:5
作者
Jahan-Mihan, Alireza [1 ]
Stevens, Priscilla [1 ]
Medero-Alfonso, Saily [1 ]
Brace, Georgina [1 ]
Overby, Laurel Kate [1 ]
Berg, Kristin [1 ]
Labyak, Corinne [1 ]
机构
[1] Univ North Florida, Dept Nutr & Dietet, 1 UNF Dr, Jacksonville, FL 32224 USA
关键词
depression; seasonal affective disorder; treatment; vitamin B; C; and D; diet; SERUM 25-HYDROXYVITAMIN D; MAJOR DEPRESSION; OXIDATIVE STRESS; B-VITAMINS; LIGHT TREATMENT; BRIGHT LIGHT; DOUBLE-BLIND; FOLIC-ACID; ANTIDEPRESSANT TREATMENT; GERIATRIC DEPRESSION;
D O I
10.3390/nu16121902
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Depression is a major global health concern expected to worsen by 2030. In 2019, 28 million individuals were affected by depressive disorders. Dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression. B vitamins are crucial for neurological function and mood regulation. Deficiencies in these vitamins are linked to depression. Studies on individual B vitamins show promise in improving depressive symptoms, particularly thiamin, riboflavin, niacin, and folate. Vitamin C deficiency may heighten depressive symptoms, but its exact role is not fully understood. Seasonal Affective Disorder (SAD) is associated with insufficient sunlight exposure and vitamin D deficiency. Vitamin D supplementation for SAD shows inconsistent results due to methodological variations. Further investigation is needed to understand the mechanisms of vitamins in depression treatment. Moreover, more research on SAD and light therapy's efficacy and underlying mechanisms involving photoreceptors, enzymes, and immune markers is needed. Although dietary and supplemental vitamins show overall favorable preventative and therapeutic effects on depression, dietitians treating psychiatric disorders face challenges due to diverse study designs, making direct comparisons difficult. Therefore, this article reviews the current literature to assess the role of dietary and supplemental vitamins in the prevention and treatment of depression. This review found that, although evidence supports the role of B vitamins and vitamins C and D in preventing and treating depression, further research is needed to clarify their mechanisms of action and determine the most effective intervention strategies.
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页数:29
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