Safety and Efficacy of the Ayurvedic Formulation Guduchi Ghana Vati as a Preventive Remedy in COVID-19

被引:0
作者
Sharma, Sanjeev [1 ]
Godatwar, Pawankumar [2 ]
Pareek, Manohar [3 ]
Meena, H. M. L. [4 ]
Sharma, Anand [5 ]
Tamoli, Sanjay [6 ]
机构
[1] Natl Inst Ayurveda, Ayurved Surg, Jaipur, India
[2] Natl Inst Ayurveda, Ayurvedic Pathol, Jaipur, India
[3] Govt Rajasthan, Ayurveda & Indian Syst Med ISM, Jaipur, Rajasthan, India
[4] Natl Inst Ayurveda, Ayurved Med, Jaipur, India
[5] Directorate Ayurveda, Ayurved Pathol, Ajmer, Rajasthan, India
[6] Target Inst Med Educ & Res, Res, Mumbai, India
关键词
guduchi; ayurveda; severity of infection; number of episodes; healthy volunteers; covid-19; prevention; tinospora cordifolia; TINOSPORA-CORDIFOLIA;
D O I
10.7759/cureus.58807
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and objectives Guduchi ( Tinospora cordifolia ) is a well-known Ayurvedic herb used as a preventive and curative remedy for various infections and immunity -related conditions. This study aimed to evaluate Guduchi Ghana Vati as a preventive remedy for COVID-19 and non-COVID-19 infections in a healthy population. Materials and methods An open -labeled, multi -centric, randomized, comparative, interventional, prospective community -based clinical study was conducted on healthy individuals at the community level in five different districts of Rajasthan by the National Institute of Ayurveda (NIA), Jaipur, India. Participants were divided into two groups. One group received Guduchi Ghana Vati as an intervention for 45 days, and the control group did not receive any intervention. Incidences of COVID-19 infection, non-COVID-19 infections, their severity, and hospitalization requirements were assessed. Safety was evaluated through monitoring of adverse reactions. Results Among the 10,022 participants who completed the study, the incidence of COVID-19 infection was found to be lower in those taking Guduchi Ghana Vati compared to the control group; however, the difference was statistically non -significant. The severity of COVID-19 based on the WHO ordinal scale was found to be significantly lower in the Guduchi Ghana Vati group compared to the control group. The number of episodes and severity of non-COVID-19 illness were also significantly lower in participants taking Guduchi Ghana Vati compared to the control group. No major adverse drug reactions were observed. Conclusion Guduchi Ghana Vati has the potential to act as a safe and effective remedy for the prevention of infection and immunity -related conditions, including COVID-19.
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页数:10
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共 20 条
[1]   COVID-19: Disease, management, treatment, and social impact [J].
Ali, Imran ;
Alharbi, Omar M. L. .
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 728
[2]  
[Anonymous], 2020, List of single drug monographs published in API, Part I,, VI
[3]  
Chunekar KC, 2006, Guduchyadi Varga. Bhavprakash Nidhantu
[4]  
Dissanayake KGC, 2020, World J. Pharmaceut. Med. Res, V6, P22
[5]   Traditional and complementary medicine during COVID-19 pandemic [J].
Ganguly, Shuvadeep ;
Bakhshi, Sameer .
PHYTOTHERAPY RESEARCH, 2020, 34 (12) :3083-3084
[6]   A Clinical Analysis of Evaluating the Usefulness and Efficacy of the Ayurvedic Drug Tinospora cordifolia in Humans [J].
Geeta, S. ;
Kamath, M. Sethukumar ;
Nagendra, K. ;
Shenoy, Revathi P. .
ADVANCED SCIENCE LETTERS, 2017, 23 (03) :2007-2008
[7]  
Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30211-7, 10.1016/S0140-6736(20)30183-5]
[8]   Natural products as a source of novel drugs for treating SARS-CoV2 infection [J].
Isidoro, Ciro ;
Chang, Ashley Chiung-Fang ;
Sheen, Lee-Yan .
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, 2022, 12 (01) :1-5
[9]  
Kalikar MV, 2008, INDIAN J PHARMACOL, V40, P107, DOI 10.4103/0253-7613.42302
[10]   Preventing COVID-19 in low- and middle-income countries COMMENT [J].
Khadka, Sitaram ;
Hashmi, Furqan K. ;
Usman, Muhammad .
DRUGS & THERAPY PERSPECTIVES, 2020, 36 (06) :250-252