Impact of blood lipid levels on venous thromboembolism in acute stroke patients

被引:0
作者
Wei, Jiapei [1 ,2 ]
Liu, Yupeng [3 ]
Lu, Xiaoqin [2 ]
Chen, Liying [1 ]
机构
[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Practice, Hangzhou 310000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Affiliated Dongyang Hosp, Dept Gen Practice, Dongyang 322100, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Biostat, 112 Nanliu Rd, Wenzhou 325000, Zhejiang, Peoples R China
关键词
Blood; Stroke; Venous thromboembolism; Risk factors; DEEP-VEIN THROMBOSIS; RISK-FACTORS; PULMONARY-EMBOLISM; PREVENTION; LIPOPROTEINS; MANAGEMENT; DISEASE;
D O I
10.1016/j.jocn.2024.02.015
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common complication of stroke with a high incidence of underdiagnosis. The relationship between dyslipidemia and VTE remains uncertain. Therefore, this study aimed to explore this connection in acute stroke patients to enhance diagnostic and preventative strategies. Methods: Retrospective data from 7854 acute stroke patients admitted to Dongyang Hospital, Affiliated with Wenzhou Medical University, between 2010 and 2020 were extracted. Differential tests were compared among various blood lipid parameters and the presence or absence of venous thrombosis. Logistic regression analysis was employed to estimate associations. Results: The prevalences of DVT and PE were 3.9 % and 1.1 %, respectively. Additionally, 43 cases (0.5 %) exhibited combined DVT and PE. A high triglyceride (TG) level was associated with a decreased risk of VTE (adjusted odd ratio [aOR] = 0.69, 95 % confidence interval [CI]: 0.54-0.89, P = 0.004), whereas a high lowdensity lipoprotein cholesterol (LDL-C) level was associated with an increased risk of VTE (aOR = 1.51, 95 % CI: 1.16-1.97, P = 0.002), after adjusting for confounding factors. No significant associations were observed for high-density lipoprotein cholesterol (HDL-C) and total cholesterol (TC) levels with VTE risk. Subgroup analyses revealed that these associations were significant in ischemic stroke patients. Conclusion: Low TG levels and high LDL-C levels were found to be associated with an increased risk of VTE in acute stroke patients, offering valuable insights for the early identification and management of high-risk individuals.
引用
收藏
页码:53 / 58
页数:6
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