A rare presentation and treatment challenges for multiple myeloma in down syndrome: A case report and literature review

被引：0

作者：

Musleh, Mais ^{[1
]}

Alhusein, Qossay ^{[2
]}

机构：

[1] AL Assad Univ Hosp, Fac Med, Dept Hematol, Al Azroni St, Sahnaya, Damascus, Syria

[2] Al Mouwasat Univ Hosp, Fac Med, Dept Hematol, Damascus, Syria

来源：

CLINICAL CASE REPORTS | 2024年 / 12卷 / 07期

关键词：

down syndrome; multiple myeloma; Syria; treatment; MEGAKARYOBLASTIC LEUKEMIA; GATA1; MUTATIONS; HYPERDIPLOIDY;

D O I：

10.1002/ccr3.9154

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Down syndrome (DS), characterized by trisomy 21, significantly increases susceptibility to leukemia, although the occurrence of multiple myeloma (MM) in DS is exceedingly rare. This report details the case of a 45-year-old female with DS who was diagnosed with MM, highlighting diagnostic and therapeutic complexities. It emphasizes the importance of tailored therapeutic strategies for treating MM in individuals with DS and the need for specialized approaches in these cases.

引用

页数：4

共 15 条

[1] Natural history of GATA1 mutations in Down syndrome [J].

Ahmed, M ;

Sternberg, A ;

Hall, G ;

Thomas, A ;

Smith, O ;

O'Marcaigh, A ;

Wynn, R ;

Stevens, R ;

Addison, M ;

King, D ;

Stewart, B ;

Gibson, B ;

Roberts, I ;

Vyas, P .

BLOOD, 2004, 103 (07) :2480-2489

[2]

[Anonymous], NCCN CLIN PRACTICE G

[3] Hematological disorders and leukemia in children with Down syndrome [J].

Bruwier, Annelyse ;

Chantrain, Christophe F. .

EUROPEAN JOURNAL OF PEDIATRICS, 2012, 171 (09) :1301-1307

[4] Understanding the role of hyperdiploidy in myeloma prognosis: which trisomies really matter? [J].

Chretien, Marie-Lorraine ;

Corre, Jill ;

Lauwers-Cances, Valerie ;

Magrangeas, Florence ;

Cleynen, Alice ;

Yon, Edwige ;

Hulin, Cyrille ;

Leleu, Xavier ;

Orsini-Piocelle, Frederique ;

Blade, Jean-Sebastien ;

Sohn, Claudine ;

Karlin, Lionel ;

Delbrel, Xavier ;

Hebraud, Benjamin ;

Roussel, Murielle ;

Marit, Gerald ;

Garderet, Laurent ;

Mohty, Mohamad ;

Rodon, Philippe ;

Voillat, Laurent ;

Royer, Bruno ;

Jaccard, Arnaud ;

Belhadj, Karim ;

Fontan, Jean ;

Caillot, Denis ;

Stoppa, Anne-Marie ;

Attal, Michel ;

Facon, Thierry ;

Moreau, Philippe ;

Minvielle, Stephane ;

Avet-Loiseau, Herve .

BLOOD, 2015, 126 (25) :2713-2719

[5] International staging system for multiple myeloma [J].

Greipp, PR ;

San Miguel, J ;

Durie, BGM ;

Crowley, JJ ;

Barlogie, B ;

Bladé, J ;

Boccadoro, M ;

Child, JA ;

Harousseau, JL ;

Kyle, RA ;

Lahuerta, JJ ;

Ludwig, H ;

Morgan, G ;

Powles, R ;

Shimizu, K ;

Shustik, C ;

Sonneveld, P ;

Tosi, P ;

Turesson, I ;

Westin, J .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (15) :3412-3420

[6] GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome [J].

Hitzler, JK ;

Cheung, J ;

Li, Y ;

Scherer, SW ;

Zipursky, A .

BLOOD, 2003, 101 (11) :4301-4304

[7] Cytogenetic classification in Korean multiple myeloma patients: prognostic significance of hyperdiploidy with 47-50 chromosomes and the number of structural abnormalities [J].

Lim, Ji-Hun ;

Seo, Eul-Ju ;

Park, Chan-Jeoung ;

Jang, Seongsoo ;

Chi, Hyun-Sook ;

Suh, Cheolwon ;

Kim, Hawk ;

Kim, Sung-Ryul .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2014, 92 (04) :313-320

[8] Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome [J].

Malinge, Sebastien ;

Bliss-Moreau, Meghan ;

Kirsammer, Gina ;

Diebold, Lauren ;

Chlon, Timothy ;

Gurbuxani, Sandeep ;

Crispino, John D. .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) :948-962

[9] Tumorigenesis in Down's syndrome: big lessons from a small chromosome [J].

Nizetic, Dean ;

Groet, Juergen .

NATURE REVIEWS CANCER, 2012, 12 (10) :721-732

[10] Germ line mutations associated with leukemias [J].

Porter, Christopher C. .

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM, 2016, :302-308

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