The footprint of gut microbiota in gallbladder cancer: a mechanistic review

被引:5
作者
Liu, Shujie [1 ,2 ,3 ]
Li, Weijian [4 ,5 ,6 ,7 ]
Chen, Jun [4 ,5 ,6 ,7 ]
Li, Maolan [4 ,5 ,6 ,7 ]
Geng, Yajun [4 ,5 ,6 ,7 ]
Liu, Yingbin [4 ,5 ,6 ,7 ]
Wu, Wenguang [4 ,5 ,6 ,7 ]
机构
[1] Nanchang Univ, Joint Program, Nanchang, Jiangxi, Peoples R China
[2] Nanchang Univ, Jiangxi Med Coll, Nanchang, Jiangxi, Peoples R China
[3] Queen Mary Univ London, London, England
[4] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Biliary Pancreat Surg, Shanghai, Peoples R China
[5] Shanghai Key Lab Biliary Tract Dis Res, Shanghai, Peoples R China
[6] Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China
[7] Shanghai Res Ctr Biliary Tract Dis, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
bacteria; gallbladder cancer; virulence factors; metabolites; chronic inflammation; biofilm formation; viruses; fungi; HELICOBACTER-PYLORI INFECTION; RED CHILI-PEPPER; GALL-BLADDER; ASSOCIATION; CARCINOMA; BILE; RISK; CELL; CHOLECYSTITIS; PROGRESSION;
D O I
10.3389/fcimb.2024.1374238
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.
引用
收藏
页数:17
相关论文
共 180 条
[1]   Acute acalculous cholecystitis in a patient with primary Epstein-Barr virus infection: a case report and literature review [J].
Agergaard, J. ;
Larsen, C. S. .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2015, 35 :67-72
[2]   Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery [J].
Albaugh, Vance L. ;
Banan, Babak ;
Antoun, Joseph ;
Xiong, Yanhua ;
Guo, Yan ;
Ping, Jie ;
Alikhan, Muhammed ;
Clements, Blake Austin ;
Abumrad, Naji N. ;
Flynn, Charles Robb .
GASTROENTEROLOGY, 2019, 156 (04) :1041-+
[3]   Mutator phenotypes due to DNA replication infidelity [J].
Arana, Mercedes E. ;
Kunkel, Thomas A. .
SEMINARS IN CANCER BIOLOGY, 2010, 20 (05) :304-311
[4]   Aflatoxin Contamination of Red Chili Pepper From Bolivia and Peru, Countries with High Gallbladder Cancer Incidence Rates [J].
Asai, Takao ;
Tsuchiya, Yasuo ;
Okano, Kiyoshi ;
Piscoya, Alejandro ;
Nishi, Carlos Yoshito ;
Ikoma, Toshikazu ;
Oyama, Tomizo ;
Ikegami, Kikuo ;
Yamamoto, Masaharu .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (10) :5167-5170
[5]   Homologues of bacterial TnpB_IS605 are widespread in diverse eukaryotic transposable elements [J].
Bao, Weidong ;
Jurka, Jerzy .
MOBILE DNA, 2013, 4
[6]   Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target? [J].
Belli, Martina ;
Barone, Lucy ;
Longo, Susanna ;
Prandi, Francesca Romana ;
Lecis, Dalgisio ;
Mollace, Rocco ;
Margonato, Davide ;
Muscoli, Saverio ;
Sergi, Domenico ;
Federici, Massimo ;
Barilla, Francesco .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
[7]   Combination, Modulation and Interplay of Modern Radiotherapy with the Tumor Microenvironment and Targeted Therapies in Pancreatic Cancer: Which Candidates to Boost Radiotherapy? [J].
Benkhaled, Sofian ;
Peters, Cedric ;
Jullian, Nicolas ;
Arsenijevic, Tatjana ;
Navez, Julie ;
Van Gestel, Dirk ;
Moretti, Luigi ;
Van Laethem, Jean-Luc ;
Bouchart, Christelle .
CANCERS, 2023, 15 (03)
[8]   Composition and Associations of the Infant Gut Fungal Microbiota with Environmental Factors and Childhood Allergic Outcomes [J].
Boutin, Rozlyn C. T. ;
Sbihi, Hind ;
McLaughlin, Ryan J. ;
Hahn, Aria S. ;
Konwar, Kishori M. ;
Loo, Rachelle S. ;
Dai, Darlene ;
Petersen, Charisse ;
Brinkman, Fiona S. L. ;
Winsor, Geoffrey L. ;
Sears, Malcolm R. ;
Moraes, Theo J. ;
Becker, Allan B. ;
Azad, Meghan B. ;
Mandhane, Piush J. ;
Subbarao, Padmaja ;
Turvey, Stuart E. ;
Finlay, B. Brett .
MBIO, 2021, 12 (03)
[9]   Characterization of a pathway of genomic instability induced by R-loops and its regulation by topoisomerases in E. coli [J].
Brochu, Julien ;
Vlachos-Breton, Emilie ;
Irsenco, Dina ;
Drolet, Marc .
PLOS GENETICS, 2023, 19 (05)
[10]   Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties [J].
Bucciantini, Monica ;
Leri, Manuela ;
Nardiello, Pamela ;
Casamenti, Fiorella ;
Stefani, Massimo .
ANTIOXIDANTS, 2021, 10 (07)