Exploring the role of autophagy in psoriasis pathogenesis: Insights into sustained inflammation and dysfunctional keratinocyte differentiation

被引：5

作者：

Wu, Xinxin ^{[1
]}

Song, Jiankun

Zhang, Ying ^{[1
]}

Kuai, Le ^{[2
,3
]}

Liu, Changya ^{[4
]}

Ma, Xin

Li, Bin ^{[1
,3
]}

Zhang, Zhan ^{[2
,3
]}

Luo, Ying ^{[2
,3
]}

机构：

[1] Tongji Univ, Shanghai Skin Dis Hosp, Inst Dermatol, Sch Med, Shanghai 200443, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Dermatol, Shanghai 200437, Peoples R China

[3] Shanghai Acad Tradit Chinese Med, Inst Dermatol, Shanghai 201203, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200030, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2024年 / 135卷

关键词：

Psoriasis; Autophagy; Inflammation; Proliferation; Differentiation; Angiogenesis; ARYL-HYDROCARBON RECEPTOR; IN-VITRO; DENDRITIC CELLS; TNF-ALPHA; SKIN; PROTEIN; EXPRESSION; PROGRANULIN; DEGRADATION; INHIBITOR;

D O I：

10.1016/j.intimp.2024.112244

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis is a common and prevalent chronic papulosquamous cutaneous disorder characterized by sustained inflammation, uncontrolled keratinocyte proliferation, dysfunctional differentiation, and angiogenesis. Autophagy, an intracellular catabolic process, can be induced in response to nutrient stress. It entails the degradation of cellular constituents through the lysosomal machinery, and its association with psoriasis has been welldocumented. Nevertheless, there remains a notable dearth of research concerning the involvement of autophagy in the pathogenesis of psoriasis within human skin. This review provides a comprehensive overview of autophagy in psoriasis pathogenesis, focusing on its involvement in two key pathological manifestations: sustained inflammation and uncontrolled keratinocyte proliferation and differentiation. Additionally, it discusses potential avenues for disease management.

引用

页数：11

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