Neurodegenerative Diseases: New Hopes and Perspectives

被引：9
作者：
Bhat, Mohammad Aadil [1 ]
Dhaneshwar, Suneela [2 ]
机构：
[1] Amity Univ Uttar Pradesh, Amity Inst Pharm, Noida, UP, India
[2] Amity Univ Maharashtra, Amity Inst Pharm, Mumbai, Maharashtra, India
来源：
CURRENT MOLECULAR MEDICINE | 2024年 / 24卷 / 08期
关键词：
Alzheimer's disease; Parkinson's disease; Amyotrophic lateral sclerosis; Huntington's disease; Friedrich ataxia; Spinal muscular atrophy; SPINAL MUSCULAR-ATROPHY; TRANSGENIC MOUSE MODEL; AMYOTROPHIC-LATERAL-SCLEROSIS; PLACEBO-CONTROLLED TRIAL; FRONTOTEMPORAL LOBAR DEGENERATION; RECOMBINANT-HUMAN-ERYTHROPOIETIN; MUTANT HUNTINGTIN EXPRESSION; ETHYL-EICOSAPENTAENOIC ACID; STRIATAL CELL-DEATH; DOUBLE-BLIND TRIAL;
D O I：
10.2174/1566524023666230907093451
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and Friedrich ataxia are all incurable neurodegenerative diseases defined by the continuous progressive loss of distinct neuronal subtypes. Despite their rising prevalence among the world's ageing population, fewer advances have been made in the concurrent massive efforts to develop newer drugs. Recently, there has been a shift in research focus towards the discovery of new therapeutic agents for neurodegenerative diseases. In this review, we have summarized the recently developed therapies and their status in the management of neurodegenerative diseases.
引用
收藏
页码：1004 / 1032
页数：29
相关论文
共 275 条
[1]   Nutrition and AGE-ing: Focusing on Alzheimer's Disease [J].
Abate, Giulia ;
Marziano, Mariagrazia ;
Rungratanawanich, Wiramon ;
Memo, Maurizio ;
Uberti, Daniela .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017
[2]   Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial [J].
Abe, Koji ;
Aoki, Masashi ;
Tsuji, Shoji ;
Itoyama, Yasuto ;
Sobue, Gen ;
Togo, Masanori ;
Hamada, Chikuma ;
Tanaka, Masahiko ;
Akimoto, Makoto ;
Nakamura, Kazue ;
Takahashi, Fumihiro ;
Kondo, Kazuoki ;
Yoshino, Hiide .
LANCET NEUROLOGY, 2017, 16 (07) :505-512
[3]   Neuroprotective and neurotoxic effects of monoamine oxidase-B inhibitors and derived metabolites under ischemia in PC12 cells [J].
Abu-Raya, S ;
Tabakman, R ;
Blaugrund, E ;
Trembovler, V ;
Lazarovici, P .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 434 (03) :109-116
[4]   Recombinant Human Erythropoietin Increases Frataxin Protein Expression Without Increasing mRNA Expression [J].
Acquaviva, Fabio ;
Castaldo, Imma ;
Filla, Alessandro ;
Giacchetti, Manuela ;
Marmolino, Daniele ;
Monticelli, Antonella ;
Pinelli, Michele ;
Sacca, Francesco ;
Cocozza, Sergio .
CEREBELLUM, 2008, 7 (03) :360-365
[5]   Nrf2 signaling pathway: Pivotal roles in inflammation [J].
Ahmed, Syed Minhaj Uddin ;
Luo, Lin ;
Namani, Akhileshwar ;
Wang, Xiu Jun ;
Tang, Xiuwen .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (02) :585-597
[6]   An estimate of amyotrophic lateral sclerosis heritability using twin data [J].
Al-Chalabi, A. ;
Fang, F. ;
Hanby, M. F. ;
Leigh, P. N. ;
Shaw, C. E. ;
Ye, W. ;
Rijsdijk, F. .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 (12) :1324-1326
[7]   Health outcomes in spinal muscular atrophy type 1 following AVXS-101 gene replacement therapy [J].
Al-Zaidy, Samiah ;
Pickard, A. Simon ;
Kotha, Kavitha ;
Alfano, Lindsay N. ;
Lowes, Linda ;
Paul, Grace ;
Church, Kathleen ;
Lehman, Kelly ;
Sproule, Douglas M. ;
Dabbous, Omar ;
Maru, Benit ;
Berry, Katherine ;
Arnold, W. David ;
Kissel, John T. ;
Mendell, Jerry R. ;
Shell, Richard .
PEDIATRIC PULMONOLOGY, 2019, 54 (02) :179-185
[8]   Therapeutics of Alzheimer's disease: Past, present and future [J].
Anand, R. ;
Gill, Kiran Dip ;
Mahdi, Abbas Ali .
NEUROPHARMACOLOGY, 2014, 76 :27-50
[9]  
ANDERMANN F, 1976, Canadian Journal of Neurological Sciences, V3, P275
[10]  
Andrich J, 2004, J NEURAL TRANSM-SUPP, P111
12345678910