Insights into neurosteroids and their role in women with epilepsy

被引：0

作者：

Vadlamudi, Lata ^{[1
,2
]}

Ashley, Daniel Paul ^{[3
,4
]}

Voinescu, P. Emanuela ^{[5
]}

机构：

[1] Univ Queensland, UQ Ctr Clin Res, Brisbane, Qld, Australia

[2] Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld, Australia

[3] Ochsner Hlth, Ochsner Clin Sch, New Orleans, LA USA

[4] Univ Queensland, Fac Med, Brisbane, Qld, Australia

[5] Harvard Med Sch, Div Epilepsy, Dept Neurol, Brigham & Womens Hosp,Div Womens Hlth, Boston, MA 02115 USA

来源：

FRONTIERS IN GLOBAL WOMENS HEALTH | 2024年 / 5卷

关键词：

women; neurosteroids; epilepsy; seizure; progesterone; sex steroids; oestrogen; GABA-A receptor; TONIC INHIBITION; PROGESTERONE; BRAIN; HIPPOCAMPUS; ESTROGEN; THERAPY; CYCLE; BDNF;

D O I：

10.3389/fgwh.2024.1363470

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Epilepsy, is a serious neurological condition, characterized by recurring, unprovoked seizures and affects over 50 million people worldwide. Epilepsy has an equal prevalence in males and females, and occurs throughout the life span. Women with epilepsy (WWE) present with unique challenges due to the cyclical fluctuation of sex steroid hormone concentrations during their life course. These shifts in sex steroid hormones and their metabolites are intricately intertwined with seizure susceptibility and affect epilepsy during the life course of women in a complex manner. Here we present a review encompassing neurosteroids-steroids that act on the brain regardless of their site of synthesis in the body; the role of neurosteroids in women with epilepsy through their life-course; exogenous neurosteroid trials; and future research directions. The focus of this review is on progesterone and its derived neurosteroids, given the extensive basic research that supports their role in modulating neuronal excitability.

引用

页数：8

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