Burning down the house: Pyroptosis in the tumor microenvironment of hepatocellular carcinoma

被引：7

作者：

Cheng, Chi ^{[1
]}

Hsu, Sheng-Kai ^{[2
]}

Chen, Yen -Chun ^{[2
]}

Liu, Wangta ^{[2
]}

Shu, En -De ^{[2
]}

Chien, Ching -Ming ^{[3
]}

Chiu, Chien-Chih ^{[2
,4
,5
,6
,7
]}

Chang, Wen-Tsan ^{[8
,9
]}

机构：

[1] Kaohsiung Med Univ, Sch Med, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung 807, Taiwan

[3] Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind, Tainan 711, Taiwan

[4] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung 807, Taiwan

[5] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 804, Taiwan

[6] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

[7] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807, Taiwan

[8] Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, Taiwan

[9] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Surg, Kaohsiung 807, Taiwan

来源：

LIFE SCIENCES | 2024年 / 347卷

关键词：

Hepatocellular carcinoma (HCC); Pyroptosis; Tumor microenvironment (TME); DOWN-REGULATION; INFLAMMATORY CASPASES; CELL PROLIFERATION; GROWTH-FACTOR; CANCER; ACTIVATION; APOPTOSIS; INTERLEUKIN-1-BETA; MACROPHAGES; METASTASIS;

D O I：

10.1016/j.lfs.2024.122627

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A high mortality rate makes hepatocellular carcinoma (HCC) a difficult cancer to treat. When surgery is not possible, liver cancer patients are treated with chemotherapy. However, HCC management and treatment are difficult. Sorafenib, which is a first-line treatment for hepatocellular carcinoma, initially slows disease progression. However, sorafenib resistance limits patient survival. Recent studies have linked HCC to programmed cell death, which has increased researcher interest in therapies targeting cell death. Pyroptosis, which is an inflammatory mode of programmed cell death, may be targeted to treat HCC. Pyroptosis pathways, executors, and effects are examined in this paper. This review summarizes how pyroptosis affects the tumor microenvironment (TME) in HCC, including the role of cytokines such as IL-1 beta and IL-18 in regulating immune responses. The use of chemotherapies and their ability to induce cancer cell pyroptosis as alternative treatments and combining them with other drugs to reduce side effects is also discussed. In conclusion, we highlight the potential of inducing pyroptosis to treat HCC and suggest ways to improve patient outcomes. Studies on cancer cell pyroptosis may lead to new HCC treatments.

引用

页数：11

共 134 条

[1] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].