An integrated prognostic model for diffuse large B-cell lymphoma treated with immunochemotherapy

被引：2

作者：

Rodriguez, Marta ^{[1
,2
]}

Alonso-Alonso, Ruth ^{[1
,2
]}

Fernandez-Miranda, Ismael ^{[3
]}

Mondejar, Rufino ^{[2
,4
]}

Cereceda, Laura ^{[1
,2
]}

Trascasa, Alvaro ^{[1
]}

Conceicao, Anabel Antonio-Da ^{[1
]}

Borregon, Jennifer ^{[1
]}

Gato, Lucia ^{[1
]}

Tomas-Roca, Laura ^{[1
]}

Barcena, Carmen ^{[5
]}

Iglesias, Begona ^{[6
]}

Climent, Fina ^{[7
]}

Gonzalez-Barca, Eva ^{[8
]}

Camacho, Francisca Inmaculada ^{[9
]}

Mayordomo, Empar ^{[10
]}

Olmedilla, Gabriel ^{[11
]}

Gomez-Prieto, Pilar ^{[12
]}

Castro, Yolanda ^{[13
]}

Serrano-Lopez, Juana ^{[14
]}

Sanchez-Garcia, Joaquin ^{[15
]}

Montes-Moreno, Santiago ^{[2
,16
]}

Garcia-Cosio, Monica ^{[2
,17
]}

Martin-Acosta, Paloma ^{[2
,18
]}

Garcia, Juan F. ^{[2
,19
]}

Planelles, Maria ^{[20
]}

Quero, Cristina ^{[21
]}

Provencio, Mariano ^{[22
]}

Mahillo-Fernandez, Ignacio ^{[23
]}

Rodriguez-Pinilla, Socorro M. ^{[1
,2
]}

Derenzini, Enrico ^{[24
]}

Pileri, Stefano ^{[24
]}

Sanchez-Beato, Margarita ^{[2
,25
]}

Cordoba, Raul ^{[2
,25
]}

Piris, Miguel A. ^{[1
,2
,26
]}

机构：

[1] IIS Hosp Univ Fdn Jimenez Diaz, Pathol Dept, Madrid, Spain

[2] Ctr Biomed Network Res Canc CIBERONC, ISCIII, Madrid, Spain

[3] Lymphoma Res Grp, IIS Puerta Hierro Segovia Arana IDIPHISA, Madrid, Spain

[4] Hosp Univ Puerto Real, UGC Labs, Cadiz, Spain

[5] Hosp Univ Doce Octubre, Pathol Dept, Madrid, Spain

[6] Hosp Alvaro Cunqueiro, Pathol Dept, Vigo, Spain

[7] Hosp Univ Bellvitge, Pathol Dept, Barcelona, Spain

[8] Hosp Duran & Reynals, Inst Catala Oncol, Haematol Dept, Barcelona, Spain

[9] Hosp Univ Getafe, Pathol Dept, Madrid, Spain

[10] Hosp Univ & Politecn La Fe, Pathol Dept, Valencia, Spain

[11] Hosp Univ La Paz, Pathol Dept, Madrid, Spain

[12] Hosp Univ La Paz, Haematol Dept, Madrid, Spain

[13] Hosp Univ Principe Asturias, Pathol Dept, Madrid, Spain

[14] IIS Hosp Univ Fdn Jimenez Diaz, Expt Hematol Lab, Madrid, Spain

[15] Univ Cordoba, Hosp Univ Reina Sofia, Maimonides Biomed Res Inst, Haematol Dept, Cordoba, Spain

[16] Hosp Univ Marques de Valdecilla, Pathol Dept, Santander, Spain

[17] Hosp Univ Ramon y Cajal, Pathol Dept, Madrid, Spain

[18] Hosp Univ Puerta Hierro, Pathol Dept, Madrid, Spain

[19] MD Anderson Canc Ctr, Pathol Dept, Madrid, Spain

[20] Hosp Gen Univ Alicante, Pathol Dept, Alicante, Spain

[21] Hosp Gen Univ Virgen de la Victoria, Complejo Hosp Costa Sol, Clin Oncol Dept, Marbella, Malaga, Spain

[22] Clin Oncol Dept, IIS Puerta Hierro Segovia Arana IDIPHISA, Madrid, Spain

[23] IIS Hosp Univ Fdn Jimenez Diaz, Dept Epidemiol, Madrid, Spain

[24] IEO European Inst Oncol IRCCS, Div Haematooncol & Haematopathol, Milan, Italy

[25] IIS Hosp Univ Fdn Jimenez Diaz, Haematol Dept, =, Madrid, Spain

[26] Hosp Univ Fdn Jimenez Diaz, Inst Invest Sanitaria Fdn Jimenez Diaz, Dept Pathol, Av Reyes Catolicos 2, E-28040 Madrid, Spain

来源：

EJHAEM | 2022年 / 3卷 / 03期

关键词：

DLBCL; gene expression; immunochemotherapy; diffuse large B-cell lymphoma; prognosis; RITUXIMAB PLUS CYCLOPHOSPHAMIDE; GENE-EXPRESSION; MOLECULAR CLASSIFICATION; R-CHOP; SURVIVAL; MYC; BCL2; RISK; PREDICTS; ORIGIN;

D O I：

10.1002/jha2.457

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diffuse large B-cell lymphoma (DLBCL), the most frequent non-Hodgkin's lymphoma subtype, is characterized by strong biological, morphological, and clinical heterogeneity, but patients are treated with immunochemotherapy in a relatively homogeneous way. Here, we have used a customized NanoString platform to analyze a series of 197 homogeneously treated DLBCL cases. The platform includes the most relevant genes or signatures known to be useful for predicting response to R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) in DLBCL cases. We generated a risk score that combines the International Prognostic Index with cell of origin and double expression of MYC/BCL2, and stratified the series into three groups, yielding hazard ratios from 0.15 to 5.49 for overall survival, and from 0.17 to 5.04 for progression-free survival. Group differences were highly significant (p < 0.0001), and the scoring system was applicable to younger patients (<60 years of age) and patients with advanced or localized stages of the disease. Results were validated in an independent dataset from 166 DLBCL patients treated in two distinct clinical trials. This risk score combines clinical and biological data in a model that can be used to integrate biological variables into the prognostic models for DLBCL cases.

引用

页码：722 / 733

页数：12

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