Formal Synthesis of (+)-Sinefungin by Way of Sequential Asymmetric Metal Catalysis

被引：0

作者：

Dey, Raghunath ^{[1
]}

Jang, Dong-Jin ^{[1
]}

Rhee, Young Ho ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Pohang 37673, Kyungbuk, South Korea

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 18期

基金：

新加坡国家研究基金会;

关键词：

S-ADENOSYLHOMOCYSTEINE; POTENT INHIBITOR; SINEFUNGIN;

D O I：

10.1021/acs.orglett.4c01196

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report a de novo approach toward (+)-sinefungin, a potent inhibitor of the physiological methyl transfer process. A key feature is represented by the sequential metal catalysis combining Pd-catalyzed hydroalkoxylation and ring-rearrangement metathesis. The unique advantage of the method is highlighted by the unprecedented complete control of the C-6 stereocenter.

引用

页码：3957 / 3960

页数：4

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